Background: The diagnosis of Graves' disease (GD) is typically confirmed with a thyroid stimulating immunoglobulin (TSI) titer. While TSI is reported to be positive in >90% of patients with GD, our anecdotal experience suggests that TSI negative GD may be more common in children. Aim: To investigate the incidence of TSI negative GD in our population and to compare patients with TSI negative vs TSI positive GD. Methods: Charts of children with GD seen in our pediatric endocrinology clinic over the past 5 years were reviewed. Results: Fifty-seven patients with GD were included. TSI was negative in 43% of patients. No significant differences were found in children with TSI negative vs TSI positive GD. Conclusions: In patients with GD, the finding of a negative TSI titer usually creates diagnostic uncertainty. However, the fact that nearly half of our patients with GD were TSI negative suggests that this is common in children.
- Graves' disease
- Thyroid antibodies
- Thyroid binding inhibitory immunoglobulin
- Thyroid stimulating immunoglobulin
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Pediatrics, Perinatology, and Child Health