Thyrotropin-receptor-mediated diseases: A paradigm for receptor autoimmunity

Bellur S. Prabhakar, Ji Lao Fan, Gattadahalli S. Seetharamaiah

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Autoantibodies to the thyrotropin receptor (TSHR) can act as thyrotropin agonists or antagonists, or can cause thyroid hypertrophy. Neither the autoantibody-binding sites on the TSHR nor the intracellular mechanisms by which the autoantibodies mediate their diverse functional effects are completely understood. This article reviews how cloning of the TSHR has contributed to our understanding of its structure and function, and has allowed induction of experimental autoimmunity to the TSHR.

Original languageEnglish (US)
Pages (from-to)437-442
Number of pages6
JournalImmunology Today
Volume18
Issue number9
DOIs
StatePublished - Sep 1 1997

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ASJC Scopus subject areas

  • Immunology

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