Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats.

D. C. Thurmond, A. B. Tang, M. T. Nakamura, J. S. Stern, S. D. Phinney

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Obese Zucker rats (fa/fa) have low levels of arachidonic acid (AA) in liver phospholipids (PL). We have previously shown that a 70% gamma-linolenate concentrate (GLA; an AA intermediate) fed at a fixed dose (0.07 g/day) normalized hepatic PL AA and reduced weight gain selectively in the obese animals. In a follow-up study, 16 obese (fa/fa) and 16 lean (Fa/Fa) 4-week-old male rats were randomized into 4 groups of 8 each and gavaged daily with soybean oil (SOY) containing 55% 18:2omega6 (an AA precursor) or GLA, using a progressive dose (<or = 5% of total calories) based on body weight. A defined diet with 11% of energy as SOY was fed ad libitum for 60 days. GLA obese had lower body weight (p

Original languageEnglish (US)
Pages (from-to)118-125
Number of pages8
JournalObesity Research
Volume1
Issue number2
StatePublished - Mar 1993
Externally publishedYes

Fingerprint

Zucker Rats
Hyperphagia
overeating
alpha-Linolenic Acid
arachidonic acid
Arachidonic Acid
Weight Gain
erythrocytes
Fatty Acids
Erythrocytes
fatty acid composition
weight gain
Soybean Oil
rats
Growth
soybean oil
Phospholipids
phospholipids
Body Weight
liver

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. / Thurmond, D. C.; Tang, A. B.; Nakamura, M. T.; Stern, J. S.; Phinney, S. D.

In: Obesity Research, Vol. 1, No. 2, 03.1993, p. 118-125.

Research output: Contribution to journalArticle

Thurmond, D. C. ; Tang, A. B. ; Nakamura, M. T. ; Stern, J. S. ; Phinney, S. D. / Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. In: Obesity Research. 1993 ; Vol. 1, No. 2. pp. 118-125.
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