Timing of plasma exchange therapy for thrombotic thrombocytopenia purpura

A brief clinical observation

Christopher R. Colflesh, Rajiv Agarwal, James P. Knochel

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Plasma exchange is the mainstay of therapy for thrombotic thrombocytopenia purpura. In this study, the authors retrospectively examined variables that may predict outcome in 18 patients with thrombotic thrombocytopenia purpura. They found that the time to first plasma exchange from admission and time to first dose of intravenous steroid are important in influencing outcome. A rise in platelets and a fall in lactic dehydrogenase 3 days after plasma exchange were also found useful in predicting survival. Therefore, early recognition and intervention in this disease is warranted.

Original languageEnglish (US)
Pages (from-to)167-168
Number of pages2
JournalAmerican Journal of the Medical Sciences
Volume311
Issue number4
DOIs
StatePublished - Apr 1996
Externally publishedYes

Fingerprint

Plasma Exchange
Purpura
Thrombocytopenia
Observation
Oxidoreductases
Milk
Therapeutics
Blood Platelets
Steroids
Survival

Keywords

  • Outcomes
  • Plasma exchange
  • Platelets
  • Steroids
  • Thrombotic thrombocytopenia purpura

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Timing of plasma exchange therapy for thrombotic thrombocytopenia purpura : A brief clinical observation. / Colflesh, Christopher R.; Agarwal, Rajiv; Knochel, James P.

In: American Journal of the Medical Sciences, Vol. 311, No. 4, 04.1996, p. 167-168.

Research output: Contribution to journalArticle

@article{8a2a58e72b88416a9d2d928e441cb227,
title = "Timing of plasma exchange therapy for thrombotic thrombocytopenia purpura: A brief clinical observation",
abstract = "Plasma exchange is the mainstay of therapy for thrombotic thrombocytopenia purpura. In this study, the authors retrospectively examined variables that may predict outcome in 18 patients with thrombotic thrombocytopenia purpura. They found that the time to first plasma exchange from admission and time to first dose of intravenous steroid are important in influencing outcome. A rise in platelets and a fall in lactic dehydrogenase 3 days after plasma exchange were also found useful in predicting survival. Therefore, early recognition and intervention in this disease is warranted.",
keywords = "Outcomes, Plasma exchange, Platelets, Steroids, Thrombotic thrombocytopenia purpura",
author = "Colflesh, {Christopher R.} and Rajiv Agarwal and Knochel, {James P.}",
year = "1996",
month = "4",
doi = "10.1097/00000441-199604000-00002",
language = "English (US)",
volume = "311",
pages = "167--168",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Timing of plasma exchange therapy for thrombotic thrombocytopenia purpura

T2 - A brief clinical observation

AU - Colflesh, Christopher R.

AU - Agarwal, Rajiv

AU - Knochel, James P.

PY - 1996/4

Y1 - 1996/4

N2 - Plasma exchange is the mainstay of therapy for thrombotic thrombocytopenia purpura. In this study, the authors retrospectively examined variables that may predict outcome in 18 patients with thrombotic thrombocytopenia purpura. They found that the time to first plasma exchange from admission and time to first dose of intravenous steroid are important in influencing outcome. A rise in platelets and a fall in lactic dehydrogenase 3 days after plasma exchange were also found useful in predicting survival. Therefore, early recognition and intervention in this disease is warranted.

AB - Plasma exchange is the mainstay of therapy for thrombotic thrombocytopenia purpura. In this study, the authors retrospectively examined variables that may predict outcome in 18 patients with thrombotic thrombocytopenia purpura. They found that the time to first plasma exchange from admission and time to first dose of intravenous steroid are important in influencing outcome. A rise in platelets and a fall in lactic dehydrogenase 3 days after plasma exchange were also found useful in predicting survival. Therefore, early recognition and intervention in this disease is warranted.

KW - Outcomes

KW - Plasma exchange

KW - Platelets

KW - Steroids

KW - Thrombotic thrombocytopenia purpura

UR - http://www.scopus.com/inward/record.url?scp=0029897748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029897748&partnerID=8YFLogxK

U2 - 10.1097/00000441-199604000-00002

DO - 10.1097/00000441-199604000-00002

M3 - Article

VL - 311

SP - 167

EP - 168

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 4

ER -