TIMP1 in conditioned media of human adipose stromal cells protects neurons against oxygen-glucose deprivation injury

Shiwei Du, Gengsheng Mao, Timothy Zhu, Zuo Luan, Yansheng Du, Huiying Gu

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Adipose stromal cells (ASC) can protect neurons when administered to brains due to secreted trophic factors. Our previous studies demonstrated that several neurotrophic factors such as brain-derived neurotropic factor (BDNF) and insulin like growth factor-1 (IGF-1) in ASC conditioned media (ASC-CM) can protect brains against hypoxic-ischemic (HI) injury in neonatal rats. In this study, we demonstrated that human ASC-CM potently blockeds caspase-3 mediated cortical neuronal apoptosis under in vitro oxygen-glucose deprivation (OGD). Interestingly, tissue inhibitor of metalloproteinase 1 (TIMP1), a non neurotrophic factor, played a significant role in the ASC-CM-induced neural protection against OGD. Thus, this study establishes the therapeutic potential of TIMP1 together with other neurotrophic factors in ASC-CM for treating cerebral HI disorders.

Original languageEnglish (US)
Pages (from-to)56-59
Number of pages4
JournalNeuroscience Letters
Volume584
DOIs
StatePublished - Jan 1 2015

Keywords

  • Adipose stromal cells
  • Oxygen-glucose deprivation
  • TIMP1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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