Tissue and gene specificity of mouse renin expression

Loren J. Field, Ross A. McGowan, Douglas P. Dickinson, Kenneth W. Gross

Research output: Contribution to journalArticle

104 Scopus citations


The Ren-1 locus of mice encodes the protease renin, which with converting enzyme processes angiotensinogen to the potent vasopressor angiotensin II. Some strains of mice appear to carry a duplication of the renin structural gene (Ren-2) near the Ren-1 locus. Strains with the gene duplication can exhibit as much as 100-fold higher levels of submaxillary gland renin compared to strains with a single gene copy. In contrast, kidney renin levels appear to be unaffected by the gene duplication. Sequence analysis of a 319 bp renin cDNA recombinant isolated from a kidney library from the two-gene strain DBA/2Ha corresponds to a transcript of the Ren-1 gene. Moreover, a single base substitution of A for G at residue #996 in the kidney renin mRNA creates a potential glycosylation recognition site that may, in part, account for the differential glvcosylation of kidney and submaxillary gland renins. In addition, our tissue surveys indicate that mature mRNAs from the Ren loci are detectable in adrenal gland and testes, as well as sublingual and parotid salivary glands, and reveal length variation for the renin transcripts in at least the submaxillary gland.

Original languageEnglish (US)
Pages (from-to)597-603
Number of pages7
Issue number4
StatePublished - Jan 1 1984
Externally publishedYes


  • Differential regulation
  • Gene duplication
  • Transcript length variation

ASJC Scopus subject areas

  • Internal Medicine

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    Field, L. J., McGowan, R. A., Dickinson, D. P., & Gross, K. W. (1984). Tissue and gene specificity of mouse renin expression. Hypertension, 6(4), 597-603. https://doi.org/10.1161/01.HYP.6.4.597