Tissue culture studies of retinal development

Samuel Shao Min Zhang, Xin Yuan Fu, Colin J. Barnstable

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Because of a limited number of cell types, a series of well-described cell-type-specific markers and a stereotyped sequence of cell development, the retina has been a valuable model of CNS development. Dissociated and explant cultures have been used to help define some of the requirements for differentiation of each major cell class. In addition to mixed-cell cultures it is now possible to use cell purification or selective growth methods to give cultures of single cell types. Alteration of gene expression by viral infection has proved to be a valuable method to help elucidate developmental pathways.

Original languageEnglish (US)
Pages (from-to)439-447
Number of pages9
JournalMethods
Volume28
Issue number4
DOIs
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)

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    Zhang, S. S. M., Fu, X. Y., & Barnstable, C. J. (2002). Tissue culture studies of retinal development. Methods, 28(4), 439-447. https://doi.org/10.1016/S1046-2023(02)00263-3