Tissue damage volume predicts organ dysfunction and inflammation after injury

Travis L. Frantz, Scott Steenburg, Greg E. Gaski, Ben L. Zarzaur, Teresa M. Bell, Tyler McCarroll, Todd O. McKinley

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Multiply injured patients (MIPs) are at risk to develop multiple-organ failure (MOF) and prolonged systemic inflammation response syndrome (SIRS). It is difficult to predict which MIPs are at the highest risk to develop these complications. We have developed a novel method that quantifies the distribution and physical magnitude of all injuries identified on admission computed tomography scanning called the Tissue Damage Volume (TDV) score. We explored how individualized TDV scores corresponded to MOF and SIRS. Materials and methods A retrospective study on 74 MIPs measured mechanical TDV by calculating injury volumes on admission computed tomography scans of all injuries in the head/neck, chest, abdomen, and pelvis. Regional and total TDV scores were compared between patients that did or did not develop MOF or sustained SIRS. The magnitude of organ dysfunction was also stratified by the magnitude of TDV. Results Mean total and pelvic TDV scores were significantly increased in patients who developed MOF. Mean total, chest, and abdominal TDV scores were increased in patients who developed sustained SIRS. The magnitude of organ dysfunction was significantly higher in patients who sustained large volume injuries in the pelvis or abdomen, and in patients who sustained injuries in at least three anatomic regions. Conclusions A novel index that quantifies the magnitude and distribution of mechanical tissue damage volume is a patient-specific index that can be used to identify patients who have sustained injury patterns that predict progression to MOF and SIRS. The preliminary methods will need refinement and prospective validation.

Original languageEnglish (US)
Pages (from-to)188-195
Number of pages8
JournalJournal of Surgical Research
Volume202
Issue number1
DOIs
StatePublished - May 1 2016

Fingerprint

Organ Size
Inflammation
Multiple Organ Failure
Wounds and Injuries
Pelvis
Abdomen
Thorax
Tomography
Tissue Distribution
Craniocerebral Trauma
Neck
Retrospective Studies

Keywords

  • Multiple-organ failure
  • Multiply injured patient
  • Systemic inflammatory response syndrome
  • Tissue Damage Volume score

ASJC Scopus subject areas

  • Surgery

Cite this

Frantz, T. L., Steenburg, S., Gaski, G. E., Zarzaur, B. L., Bell, T. M., McCarroll, T., & McKinley, T. O. (2016). Tissue damage volume predicts organ dysfunction and inflammation after injury. Journal of Surgical Research, 202(1), 188-195. https://doi.org/10.1016/j.jss.2015.12.043

Tissue damage volume predicts organ dysfunction and inflammation after injury. / Frantz, Travis L.; Steenburg, Scott; Gaski, Greg E.; Zarzaur, Ben L.; Bell, Teresa M.; McCarroll, Tyler; McKinley, Todd O.

In: Journal of Surgical Research, Vol. 202, No. 1, 01.05.2016, p. 188-195.

Research output: Contribution to journalArticle

Frantz, TL, Steenburg, S, Gaski, GE, Zarzaur, BL, Bell, TM, McCarroll, T & McKinley, TO 2016, 'Tissue damage volume predicts organ dysfunction and inflammation after injury', Journal of Surgical Research, vol. 202, no. 1, pp. 188-195. https://doi.org/10.1016/j.jss.2015.12.043
Frantz, Travis L. ; Steenburg, Scott ; Gaski, Greg E. ; Zarzaur, Ben L. ; Bell, Teresa M. ; McCarroll, Tyler ; McKinley, Todd O. / Tissue damage volume predicts organ dysfunction and inflammation after injury. In: Journal of Surgical Research. 2016 ; Vol. 202, No. 1. pp. 188-195.
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