Tissue distribution of amyloid deposits in Abyssinian cats with familial amyloidosis

S. P. DiBartola, M. J. Tarr, Merrill Benson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The tissue distribution of amyloid deposits was studied in 15 related Abyssinian cats with familial amyloidosis. There was interstitial medullary amyloidosis in the kidneys of all 15 cats but only 11 had detectable glomerular involvement. The thyroid glands, stomach and colon were affected in all cats examined. Most of the cats also had amyloid deposits in the small intestine, spleen, heart, adrenals, pancreas, liver, lymph nodes and bladder. In 50 per cent or fewer of the cats examined, there was involvement of the parathyroids, lung and gonads. The central nervous system was not involved in any of the 3 cats evaluated. In 8 of the cats, no concurrent inflammatory disease could be detected. The tissue distribution of amyloid deposits resembled that found in other breeds of domestic cats with systemic amyloidosis. Despite the wide tissue distribution of amyloid deposits, clinical signs were related to renal amyloidosis. Familial amyloidosis in the Abyssinian cat may represent a valuable spontaneous animal model for the study of Familial Mediterranean Fever in man and the pathogenesis of reactive amyloidosis in general.

Original languageEnglish
Pages (from-to)387-398
Number of pages12
JournalJournal of Comparative Pathology
Volume96
Issue number4
DOIs
StatePublished - 1986

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Familial Amyloidosis
amyloidosis
Amyloid Plaques
tissue distribution
Tissue Distribution
amyloid
Cats
cats
Amyloidosis
kidneys
Familial Mediterranean Fever
Kidney
thyroid gland
Gonads
bladder
pancreas
Small Intestine
fever
colon
central nervous system

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Tissue distribution of amyloid deposits in Abyssinian cats with familial amyloidosis. / DiBartola, S. P.; Tarr, M. J.; Benson, Merrill.

In: Journal of Comparative Pathology, Vol. 96, No. 4, 1986, p. 387-398.

Research output: Contribution to journalArticle

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