Tissue penetration of cefpodoxime and cefixime in healthy subjects

Ping Liu, Markus Müller, Maria Grant, Bernd Obermann, Hartmut Derendorf

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Microdialysis is a technique that allows the measurement of free antibiotic concentrations in different tissues, which are responsible for the antibacterial activity at the infection site. In an open, randomized, 2-way crossover study in healthy volunteers, the muscle penetration of orally administered cefpodoxime (400 mg) and cefixime (400 mg) was compared using microdialysis, The results show that the total plasma concentration-time profiles of each antibiotic were similar; the area under the curve for cefpodoxime was 22.4 ± 8.7 versus 25.6 ± 8.5 mg/LFisheyeh for cefixime. However, tissue penetration was twice as high for cefpodoxime (area under the curve 15.4 ± 5.1 mg/LFisheyeh) as for cefixime (area under the curve 7.3 mg/LFisheyeh), This degree of tissue distribution is consistent with their protein binding of 21% for cefpodoxime and 65% for cefixime. After equilibration, the unbound tissue concentrations of both antibiotics were similar to their unbound plasma concentrations. Pharmacokinetic modeling was applied to describe the pharmacokinetic profiles in plasma and muscle. The study demonstrates that cefpodoxime shows greater tissue penetration than cefixime.

Original languageEnglish (US)
Pages (from-to)564-569
Number of pages6
JournalJournal of Clinical Pharmacology
Volume45
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

cefpodoxime
Cefixime
Healthy Volunteers
Area Under Curve
Microdialysis
Anti-Bacterial Agents
Pharmacokinetics
Muscles
Tissue Distribution
Protein Binding
Cross-Over Studies

Keywords

  • Cefixime
  • Cefpodoxime
  • Microdialysis
  • Pharmacokinetics
  • Tissue penetration

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Tissue penetration of cefpodoxime and cefixime in healthy subjects. / Liu, Ping; Müller, Markus; Grant, Maria; Obermann, Bernd; Derendorf, Hartmut.

In: Journal of Clinical Pharmacology, Vol. 45, No. 5, 05.2005, p. 564-569.

Research output: Contribution to journalArticle

Liu, P, Müller, M, Grant, M, Obermann, B & Derendorf, H 2005, 'Tissue penetration of cefpodoxime and cefixime in healthy subjects', Journal of Clinical Pharmacology, vol. 45, no. 5, pp. 564-569. https://doi.org/10.1177/0091270004273679
Liu, Ping ; Müller, Markus ; Grant, Maria ; Obermann, Bernd ; Derendorf, Hartmut. / Tissue penetration of cefpodoxime and cefixime in healthy subjects. In: Journal of Clinical Pharmacology. 2005 ; Vol. 45, No. 5. pp. 564-569.
@article{1382be9ea0a444de88c9a27295a9cda0,
title = "Tissue penetration of cefpodoxime and cefixime in healthy subjects",
abstract = "Microdialysis is a technique that allows the measurement of free antibiotic concentrations in different tissues, which are responsible for the antibacterial activity at the infection site. In an open, randomized, 2-way crossover study in healthy volunteers, the muscle penetration of orally administered cefpodoxime (400 mg) and cefixime (400 mg) was compared using microdialysis, The results show that the total plasma concentration-time profiles of each antibiotic were similar; the area under the curve for cefpodoxime was 22.4 ± 8.7 versus 25.6 ± 8.5 mg/LFisheyeh for cefixime. However, tissue penetration was twice as high for cefpodoxime (area under the curve 15.4 ± 5.1 mg/LFisheyeh) as for cefixime (area under the curve 7.3 mg/LFisheyeh), This degree of tissue distribution is consistent with their protein binding of 21{\%} for cefpodoxime and 65{\%} for cefixime. After equilibration, the unbound tissue concentrations of both antibiotics were similar to their unbound plasma concentrations. Pharmacokinetic modeling was applied to describe the pharmacokinetic profiles in plasma and muscle. The study demonstrates that cefpodoxime shows greater tissue penetration than cefixime.",
keywords = "Cefixime, Cefpodoxime, Microdialysis, Pharmacokinetics, Tissue penetration",
author = "Ping Liu and Markus M{\"u}ller and Maria Grant and Bernd Obermann and Hartmut Derendorf",
year = "2005",
month = "5",
doi = "10.1177/0091270004273679",
language = "English (US)",
volume = "45",
pages = "564--569",
journal = "Journal of Clinical Pharmacology",
issn = "0091-2700",
publisher = "SAGE Publications Inc.",
number = "5",

}

TY - JOUR

T1 - Tissue penetration of cefpodoxime and cefixime in healthy subjects

AU - Liu, Ping

AU - Müller, Markus

AU - Grant, Maria

AU - Obermann, Bernd

AU - Derendorf, Hartmut

PY - 2005/5

Y1 - 2005/5

N2 - Microdialysis is a technique that allows the measurement of free antibiotic concentrations in different tissues, which are responsible for the antibacterial activity at the infection site. In an open, randomized, 2-way crossover study in healthy volunteers, the muscle penetration of orally administered cefpodoxime (400 mg) and cefixime (400 mg) was compared using microdialysis, The results show that the total plasma concentration-time profiles of each antibiotic were similar; the area under the curve for cefpodoxime was 22.4 ± 8.7 versus 25.6 ± 8.5 mg/LFisheyeh for cefixime. However, tissue penetration was twice as high for cefpodoxime (area under the curve 15.4 ± 5.1 mg/LFisheyeh) as for cefixime (area under the curve 7.3 mg/LFisheyeh), This degree of tissue distribution is consistent with their protein binding of 21% for cefpodoxime and 65% for cefixime. After equilibration, the unbound tissue concentrations of both antibiotics were similar to their unbound plasma concentrations. Pharmacokinetic modeling was applied to describe the pharmacokinetic profiles in plasma and muscle. The study demonstrates that cefpodoxime shows greater tissue penetration than cefixime.

AB - Microdialysis is a technique that allows the measurement of free antibiotic concentrations in different tissues, which are responsible for the antibacterial activity at the infection site. In an open, randomized, 2-way crossover study in healthy volunteers, the muscle penetration of orally administered cefpodoxime (400 mg) and cefixime (400 mg) was compared using microdialysis, The results show that the total plasma concentration-time profiles of each antibiotic were similar; the area under the curve for cefpodoxime was 22.4 ± 8.7 versus 25.6 ± 8.5 mg/LFisheyeh for cefixime. However, tissue penetration was twice as high for cefpodoxime (area under the curve 15.4 ± 5.1 mg/LFisheyeh) as for cefixime (area under the curve 7.3 mg/LFisheyeh), This degree of tissue distribution is consistent with their protein binding of 21% for cefpodoxime and 65% for cefixime. After equilibration, the unbound tissue concentrations of both antibiotics were similar to their unbound plasma concentrations. Pharmacokinetic modeling was applied to describe the pharmacokinetic profiles in plasma and muscle. The study demonstrates that cefpodoxime shows greater tissue penetration than cefixime.

KW - Cefixime

KW - Cefpodoxime

KW - Microdialysis

KW - Pharmacokinetics

KW - Tissue penetration

UR - http://www.scopus.com/inward/record.url?scp=17644372400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17644372400&partnerID=8YFLogxK

U2 - 10.1177/0091270004273679

DO - 10.1177/0091270004273679

M3 - Article

C2 - 15831780

AN - SCOPUS:17644372400

VL - 45

SP - 564

EP - 569

JO - Journal of Clinical Pharmacology

JF - Journal of Clinical Pharmacology

SN - 0091-2700

IS - 5

ER -