Abstract
Repairing and rebuilding damaged tissue in diseased human subjects remains a daunting challenge for clinical medicine. Proper vascular formation that serves to deliver blood-borne nutrients and adequate levels of oxygen and to remove wastes is critical for successful tissue regeneration. Endothelial colony-forming cells (ECFC) represent a promising cell source for revascularization of damaged tissue. ECFCs are identified by displaying a hierarchy of clonal proliferative potential and by pronounced postnatal vascularization ability in vivo. In this review, we provide a brief overview of human ECFC isolation and characterization, a survey of a number of animal models of human disease in which ECFCs have been shown to have prominent roles in tissue repair, and a summary of current challenges that must be overcome before moving ECFC into human subjects as a cell therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 283-290 |
| Number of pages | 8 |
| Journal | Pediatric Research |
| Volume | 83 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 1 2018 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Tissue regeneration using endothelial colony-forming cells : Promising cells for vascular repair. / Banno, Kimihiko; Yoder, Mervin.
In: Pediatric Research, Vol. 83, No. 1-2, 01.01.2018, p. 283-290.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Tissue regeneration using endothelial colony-forming cells
T2 - Promising cells for vascular repair
AU - Banno, Kimihiko
AU - Yoder, Mervin
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Repairing and rebuilding damaged tissue in diseased human subjects remains a daunting challenge for clinical medicine. Proper vascular formation that serves to deliver blood-borne nutrients and adequate levels of oxygen and to remove wastes is critical for successful tissue regeneration. Endothelial colony-forming cells (ECFC) represent a promising cell source for revascularization of damaged tissue. ECFCs are identified by displaying a hierarchy of clonal proliferative potential and by pronounced postnatal vascularization ability in vivo. In this review, we provide a brief overview of human ECFC isolation and characterization, a survey of a number of animal models of human disease in which ECFCs have been shown to have prominent roles in tissue repair, and a summary of current challenges that must be overcome before moving ECFC into human subjects as a cell therapy.
AB - Repairing and rebuilding damaged tissue in diseased human subjects remains a daunting challenge for clinical medicine. Proper vascular formation that serves to deliver blood-borne nutrients and adequate levels of oxygen and to remove wastes is critical for successful tissue regeneration. Endothelial colony-forming cells (ECFC) represent a promising cell source for revascularization of damaged tissue. ECFCs are identified by displaying a hierarchy of clonal proliferative potential and by pronounced postnatal vascularization ability in vivo. In this review, we provide a brief overview of human ECFC isolation and characterization, a survey of a number of animal models of human disease in which ECFCs have been shown to have prominent roles in tissue repair, and a summary of current challenges that must be overcome before moving ECFC into human subjects as a cell therapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=85044592529&partnerID=8YFLogxK
U2 - 10.1038/pr.2017.231
DO - 10.1038/pr.2017.231
M3 - Review article
C2 - 28915234
AN - SCOPUS:85044592529
VL - 83
SP - 283
EP - 290
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 1-2
ER -