Tissue transglutaminase

A mediator and predictor of chronic allograft nephropathy?

Timothy S. Johnson, Hamdy Abo-Zenah, N. Skill, Samantha Bex, Graham Wild, Colin B. Brown, Martin Griffin, Meguid El Nahas

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. The precise mechanisms underlying the development of chronic allograft nephropathy (CAN) and the associated renal fibrosis remain uncertain. The protein-crosslinking enzyme, tissue transglutaminase (tTg), has recently been implicated in renal fibrosis. Methods. We investigated the involvement of tTg and its crosslink product, ε-(γ-glutamyl) lysine, in 23 human kidney allografts during the early posttransplantation period and related these to changes of CAN that developed in 8 of them. Sequential biopsies were investigated using immunohistochemical, immunofluorescence, and in situ enzyme activity techniques. Results. From implantation, tTg (+266%) and ε-(γ-glutamyl) lysine crosslink (+256.3%) staining increased significantly (P

Original languageEnglish (US)
Pages (from-to)1667-1675
Number of pages9
JournalTransplantation
Volume77
Issue number11
DOIs
StatePublished - Jun 15 2004
Externally publishedYes

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Allografts
Kidney
Lysine
Fibrosis
Enzymes
Fluorescent Antibody Technique
Staining and Labeling
Biopsy
transglutaminase 2
Proteins

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Johnson, T. S., Abo-Zenah, H., Skill, N., Bex, S., Wild, G., Brown, C. B., ... El Nahas, M. (2004). Tissue transglutaminase: A mediator and predictor of chronic allograft nephropathy? Transplantation, 77(11), 1667-1675. https://doi.org/10.1097/01.TP.0000131171.67671.3C

Tissue transglutaminase : A mediator and predictor of chronic allograft nephropathy? / Johnson, Timothy S.; Abo-Zenah, Hamdy; Skill, N.; Bex, Samantha; Wild, Graham; Brown, Colin B.; Griffin, Martin; El Nahas, Meguid.

In: Transplantation, Vol. 77, No. 11, 15.06.2004, p. 1667-1675.

Research output: Contribution to journalArticle

Johnson, TS, Abo-Zenah, H, Skill, N, Bex, S, Wild, G, Brown, CB, Griffin, M & El Nahas, M 2004, 'Tissue transglutaminase: A mediator and predictor of chronic allograft nephropathy?', Transplantation, vol. 77, no. 11, pp. 1667-1675. https://doi.org/10.1097/01.TP.0000131171.67671.3C
Johnson, Timothy S. ; Abo-Zenah, Hamdy ; Skill, N. ; Bex, Samantha ; Wild, Graham ; Brown, Colin B. ; Griffin, Martin ; El Nahas, Meguid. / Tissue transglutaminase : A mediator and predictor of chronic allograft nephropathy?. In: Transplantation. 2004 ; Vol. 77, No. 11. pp. 1667-1675.
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