Tobacco and alcohol as risk factors for pancreatic cancer

on behalf of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of immune microenvironment in pancreatic carcinogenesis activated by tobacco and alcohol.

Original languageEnglish (US)
Pages (from-to)529-536
Number of pages8
JournalBest Practice and Research: Clinical Gastroenterology
Volume31
Issue number5
DOIs
StatePublished - Oct 2017

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Keywords

  • Alcohol
  • Genetically engineered mouse models
  • Pancreatic cancer
  • Population risk
  • Tobacco

ASJC Scopus subject areas

  • Gastroenterology

Cite this

on behalf of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) (2017). Tobacco and alcohol as risk factors for pancreatic cancer. Best Practice and Research: Clinical Gastroenterology, 31(5), 529-536. https://doi.org/10.1016/j.bpg.2017.09.001