Tobacco and alcohol as risk factors for pancreatic cancer

Murray Korc, Christie Y. Jeon, Mouad Edderkaoui, Stephen J. Pandol, Maxim S. Petrov

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of immune microenvironment in pancreatic carcinogenesis activated by tobacco and alcohol.

Original languageEnglish (US)
JournalBest Practice and Research: Clinical Gastroenterology
DOIs
StateAccepted/In press - 2017

Fingerprint

Pancreatic Neoplasms
Tobacco
Alcohols
Smoking
Tobacco Use
Smoke
Alcohol Drinking
Life Style
Cause of Death
Carcinogenesis
Population
Neoplasms

Keywords

  • Alcohol
  • Genetically engineered mouse models
  • Pancreatic cancer
  • Population risk
  • Tobacco

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Tobacco and alcohol as risk factors for pancreatic cancer. / Korc, Murray; Jeon, Christie Y.; Edderkaoui, Mouad; Pandol, Stephen J.; Petrov, Maxim S.

In: Best Practice and Research: Clinical Gastroenterology, 2017.

Research output: Contribution to journalArticle

Korc, Murray ; Jeon, Christie Y. ; Edderkaoui, Mouad ; Pandol, Stephen J. ; Petrov, Maxim S. / Tobacco and alcohol as risk factors for pancreatic cancer. In: Best Practice and Research: Clinical Gastroenterology. 2017.
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