Tolerance and morphine-induced cross-tolerance are not shown to Tyr-W-MIF-1 analgesia

Richard Bell, Anthony L. Vaccarino, Richard D. Olson, Gayle A. Olson, William L. Nores, James G. Cambre, James E. Zadina, Abba J. Kastin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Tolerance and cross-tolerance between Tyr-W-MIF-1, a mixed μ-agonist/antagonist, and morphine were examined. Opiate dependence also was examined. Rats were pretreated with Tyr-W-MIF-1, morphine, or saline for 4 days. On day 5, the animals were tested for Tyr-W-MIF-1 analgesia, morphine analgesia, or naloxone-precipitated withdrawal. Tyr-W-MIF-1- and morphine-pretreated animals showed similar levels of dependence. Animals pretreated with Tyr-W-MIF-1 failed to express tolerance to Tyr-W-MIF-1 analgesia but did display cross-tolerance to morphine analgesia. Animals pretreated with morphine displayed tolerance to morphine analgesia but did not express cross-tolerance to Tyr-W-MIF-1 analgesia. Therefore, tolerance and morphine-induced cross-tolerance were not expressed to Tyr-W-MIF-1 analgesia. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)971-978
Number of pages8
JournalPeptides
Volume20
Issue number8
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Analgesia
Morphine
Animals
Opiate Alkaloids
Opioid-Related Disorders
tyrosyl-prolyl-tryptophyl-glycinamide
Naloxone
Rats

Keywords

  • Nociception
  • Opioid
  • Pain
  • Peptide
  • Tyr-MIF-1

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Bell, R., Vaccarino, A. L., Olson, R. D., Olson, G. A., Nores, W. L., Cambre, J. G., ... Kastin, A. J. (1999). Tolerance and morphine-induced cross-tolerance are not shown to Tyr-W-MIF-1 analgesia. Peptides, 20(8), 971-978. https://doi.org/10.1016/S0196-9781(99)00090-X

Tolerance and morphine-induced cross-tolerance are not shown to Tyr-W-MIF-1 analgesia. / Bell, Richard; Vaccarino, Anthony L.; Olson, Richard D.; Olson, Gayle A.; Nores, William L.; Cambre, James G.; Zadina, James E.; Kastin, Abba J.

In: Peptides, Vol. 20, No. 8, 1999, p. 971-978.

Research output: Contribution to journalArticle

Bell, R, Vaccarino, AL, Olson, RD, Olson, GA, Nores, WL, Cambre, JG, Zadina, JE & Kastin, AJ 1999, 'Tolerance and morphine-induced cross-tolerance are not shown to Tyr-W-MIF-1 analgesia', Peptides, vol. 20, no. 8, pp. 971-978. https://doi.org/10.1016/S0196-9781(99)00090-X
Bell, Richard ; Vaccarino, Anthony L. ; Olson, Richard D. ; Olson, Gayle A. ; Nores, William L. ; Cambre, James G. ; Zadina, James E. ; Kastin, Abba J. / Tolerance and morphine-induced cross-tolerance are not shown to Tyr-W-MIF-1 analgesia. In: Peptides. 1999 ; Vol. 20, No. 8. pp. 971-978.
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