Tolerance to ethanol analgesia is not accompanied by cross-tolerance to morphine analgesia in rats

Richard L. Bell, Richard D. Olson, Anthony L. Vaccarino

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

In the present study, we examined the development of environment- independent and environment-dependent tolerance to ethanol-induced analgesia (EIA) and cross-tolerance with morphine-induced analgesia (MIA). To examine the development of environment-independent tolerance, male Long-Evans rats were given increasing amounts of ethanol (5 days each of 5% (v/v), 10% (v/v), and 15% (v/v)) added to their drinking water over a 15-day period. A control group was given plain tap water to drink. On day 16, all rats were given plain tap water to drink. On day 17, the animals were tested for EIA (2.5 g/kg, IP) or MIA (10 mg/kg, IP) in the hot plate test. To examine the development of environment-dependent tolerance, animals were injected with ethanol (2.5 g/kg, IP) or an equal volume of saline once a day for 2 days. On day 3, the animals received no treatment. On day 4, the animals were tested for either EIA (25 g/kg, IP) or MIA (10 mg/kg, IP) in the hot plate test. It was found that rats pretreated with ethanol (both self-administration, and IP injections) displayed tolerance to EIA, which was not accompanied by cross- tolerance to MIA.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume59
Issue number1
DOIs
StatePublished - Jan 1 1998

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Keywords

  • Analgesia
  • Associative
  • Environm ent dependent
  • Environment independent
  • Ethanol
  • Morphine
  • Nonassociative
  • Pain
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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