Tolerance to Ethanol Hypothermia in Inbred Mice: Genotypic Correlations with Behavioral Responses

John C. Crabbe, Jeri S. Janowsky, Emmett R. Young, Ann Kosobud, Julianne Stack, Henk Rigter

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Hypothermia was studied 5 min before, and 30 and 60 min after intraperitoneal administration of ethanol (3 g/kg) in 20 inbred strains of mice. Ethanol was given daily for 8 days, and temperatures were taken on Days 1, 3, 5, and 8. Tolerance was indexed by the reduction in hypothermia over days. There were large strain differences in baseline temperature, the hypothermic effect of ethanol, and in development of tolerance to hypothermia. Some strains of mice DBA/1J, DBA/2N, MA/MyJ, and PL/J) did not develop tolerance to the hypothermic effect of ethanol. Initial sensitivity to the hypothermic effect of ethanol was significantly genetically correlated with tolerance development, indicating control of these responses by common genes. Ethanol-induced changes in activity and ataxia, as well as blood ethanol concentrations, were also assessed. Although there were significant strain differences in activity reduction, ataxia, blood-ethanol concentrations, and changes in these parameters during the course of chronic treatment, none of these variables could explain the genetic differences in hypothermic sensitivity and tolerance.

Original languageEnglish (US)
Pages (from-to)446-458
Number of pages13
JournalAlcoholism: Clinical and Experimental Research
Volume6
Issue number4
DOIs
StatePublished - Sep 1982
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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