Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury

Yue Wang, Aaron M. Abarbanell, Jeremy L. Herrmann, Brent R. Weil, Jeffrey Poynter, Mariuxi C. Manukyan, Paul R. Crisostomo, Daniel R. Meldrum

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) play a key role in innate immune defenses. After activation by foreign pathogens or host-derived molecules, TLRs signal via overlapping or distinct signaling cascades and eventually induce numerous genes involved in a variety of cellular responses. A growing body of evidence suggests that TLR signaling also plays an important role in cardiac ischemia/reperfusion injury. We review our current understanding of the TLR signaling pathways and their roles in the pathophysiology of cardiac ischemia/reperfusion injury, as well as discuss several mechanisms for TLR activation and regulation.

Original languageEnglish
Pages (from-to)548-557
Number of pages10
JournalShock
Volume34
Issue number6
DOIs
StatePublished - Dec 2010

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Toll-Like Receptors
Reperfusion Injury
Genes

Keywords

  • ischemia/reperfusion injury
  • signaling pathways
  • Toll-like receptor

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Wang, Y., Abarbanell, A. M., Herrmann, J. L., Weil, B. R., Poynter, J., Manukyan, M. C., ... Meldrum, D. R. (2010). Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury. Shock, 34(6), 548-557. https://doi.org/10.1097/SHK.0b013e3181e686f5

Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury. / Wang, Yue; Abarbanell, Aaron M.; Herrmann, Jeremy L.; Weil, Brent R.; Poynter, Jeffrey; Manukyan, Mariuxi C.; Crisostomo, Paul R.; Meldrum, Daniel R.

In: Shock, Vol. 34, No. 6, 12.2010, p. 548-557.

Research output: Contribution to journalArticle

Wang, Y, Abarbanell, AM, Herrmann, JL, Weil, BR, Poynter, J, Manukyan, MC, Crisostomo, PR & Meldrum, DR 2010, 'Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury', Shock, vol. 34, no. 6, pp. 548-557. https://doi.org/10.1097/SHK.0b013e3181e686f5
Wang, Yue ; Abarbanell, Aaron M. ; Herrmann, Jeremy L. ; Weil, Brent R. ; Poynter, Jeffrey ; Manukyan, Mariuxi C. ; Crisostomo, Paul R. ; Meldrum, Daniel R. / Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury. In: Shock. 2010 ; Vol. 34, No. 6. pp. 548-557.
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