Toothpaste factors related to dentine tubule occlusion and dentine protection against erosion and abrasion

Samira Helena João-Souza, Leticia Oba Sakae, Adrian Lussi, Ana Cecilia Corrêa Aranha, Anderson Hara, Tommy Baumann, Tais Scaramucci, Thiago Saads Carvalho

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate the effect of toothpastes on dentine surface loss and tubule occlusion, and the association of toothpaste-related factors to each of the outcomes. Materials and methods: One hundred and sixty human dentine specimens were randomly distributed into 10 groups, according to different toothpastes. The specimens were submitted to artificial saliva (60 min), citric acid (3 min), and brushing abrasion (25 s; totalizing 2 min in toothpaste slurries). This was repeated five times and two outcome variables were analyzed: dentine surface loss (dSL; μm) and tubule occlusion by measurement of the total area of open tubules (Area-OT; μm2). Data were analyzed with Kruskal-Wallis and Mann-Whitney tests (α = 0.05); bivariate and multivariate regressions were used to model the association of the chemical (pH, concentration of F, Ca2+, and PO4 3− and presence of Sn2+) and physical (% weight of solid particles, particle size, and wettability) factors of the toothpastes to both outcome variables. Results: Toothpastes caused different degrees of dSL and did not differ in Area-OT. All chemical and physical factors, except the presence of Sn2+, were associated with dSL (p < 0.001). Area-OT was associated only with the presence of Sn2+ (p = 0.033). Conclusion: Greater dSL was associated with lower pH, lower concentration of F, higher concentration of Ca2+ and PO4 3−, greater % weight of solid particles, smaller particle size, and lesser wettability, whereas tubule occlusion was associated with the presence of Sn2+. Clinical relevance: Depending on their chemical and physical composition, toothpastes will cause different degrees of dentine tubule occlusion and dentine surface loss. This could, in turn, modulate dentine hypersensitivity.

Original languageEnglish (US)
JournalClinical Oral Investigations
DOIs
StateAccepted/In press - Jan 1 2019

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Toothpastes
Dentin
Wettability
Particle Size
Dentin Sensitivity
Artificial Saliva
Chemical Models
Weights and Measures
Citric Acid

Keywords

  • Anti-erosion
  • Dental abrasion
  • Dental erosion
  • Dentinal tubules
  • Desensitizing
  • Toothpaste

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

João-Souza, Samira Helena ; Sakae, Leticia Oba ; Lussi, Adrian ; Aranha, Ana Cecilia Corrêa ; Hara, Anderson ; Baumann, Tommy ; Scaramucci, Tais ; Carvalho, Thiago Saads. / Toothpaste factors related to dentine tubule occlusion and dentine protection against erosion and abrasion. In: Clinical Oral Investigations. 2019.
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title = "Toothpaste factors related to dentine tubule occlusion and dentine protection against erosion and abrasion",
abstract = "Objectives: To investigate the effect of toothpastes on dentine surface loss and tubule occlusion, and the association of toothpaste-related factors to each of the outcomes. Materials and methods: One hundred and sixty human dentine specimens were randomly distributed into 10 groups, according to different toothpastes. The specimens were submitted to artificial saliva (60 min), citric acid (3 min), and brushing abrasion (25 s; totalizing 2 min in toothpaste slurries). This was repeated five times and two outcome variables were analyzed: dentine surface loss (dSL; μm) and tubule occlusion by measurement of the total area of open tubules (Area-OT; μm2). Data were analyzed with Kruskal-Wallis and Mann-Whitney tests (α = 0.05); bivariate and multivariate regressions were used to model the association of the chemical (pH, concentration of F−, Ca2+, and PO4 3− and presence of Sn2+) and physical ({\%} weight of solid particles, particle size, and wettability) factors of the toothpastes to both outcome variables. Results: Toothpastes caused different degrees of dSL and did not differ in Area-OT. All chemical and physical factors, except the presence of Sn2+, were associated with dSL (p < 0.001). Area-OT was associated only with the presence of Sn2+ (p = 0.033). Conclusion: Greater dSL was associated with lower pH, lower concentration of F−, higher concentration of Ca2+ and PO4 3−, greater {\%} weight of solid particles, smaller particle size, and lesser wettability, whereas tubule occlusion was associated with the presence of Sn2+. Clinical relevance: Depending on their chemical and physical composition, toothpastes will cause different degrees of dentine tubule occlusion and dentine surface loss. This could, in turn, modulate dentine hypersensitivity.",
keywords = "Anti-erosion, Dental abrasion, Dental erosion, Dentinal tubules, Desensitizing, Toothpaste",
author = "Jo{\~a}o-Souza, {Samira Helena} and Sakae, {Leticia Oba} and Adrian Lussi and Aranha, {Ana Cecilia Corr{\^e}a} and Anderson Hara and Tommy Baumann and Tais Scaramucci and Carvalho, {Thiago Saads}",
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doi = "10.1007/s00784-019-03069-7",
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T1 - Toothpaste factors related to dentine tubule occlusion and dentine protection against erosion and abrasion

AU - João-Souza, Samira Helena

AU - Sakae, Leticia Oba

AU - Lussi, Adrian

AU - Aranha, Ana Cecilia Corrêa

AU - Hara, Anderson

AU - Baumann, Tommy

AU - Scaramucci, Tais

AU - Carvalho, Thiago Saads

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: To investigate the effect of toothpastes on dentine surface loss and tubule occlusion, and the association of toothpaste-related factors to each of the outcomes. Materials and methods: One hundred and sixty human dentine specimens were randomly distributed into 10 groups, according to different toothpastes. The specimens were submitted to artificial saliva (60 min), citric acid (3 min), and brushing abrasion (25 s; totalizing 2 min in toothpaste slurries). This was repeated five times and two outcome variables were analyzed: dentine surface loss (dSL; μm) and tubule occlusion by measurement of the total area of open tubules (Area-OT; μm2). Data were analyzed with Kruskal-Wallis and Mann-Whitney tests (α = 0.05); bivariate and multivariate regressions were used to model the association of the chemical (pH, concentration of F−, Ca2+, and PO4 3− and presence of Sn2+) and physical (% weight of solid particles, particle size, and wettability) factors of the toothpastes to both outcome variables. Results: Toothpastes caused different degrees of dSL and did not differ in Area-OT. All chemical and physical factors, except the presence of Sn2+, were associated with dSL (p < 0.001). Area-OT was associated only with the presence of Sn2+ (p = 0.033). Conclusion: Greater dSL was associated with lower pH, lower concentration of F−, higher concentration of Ca2+ and PO4 3−, greater % weight of solid particles, smaller particle size, and lesser wettability, whereas tubule occlusion was associated with the presence of Sn2+. Clinical relevance: Depending on their chemical and physical composition, toothpastes will cause different degrees of dentine tubule occlusion and dentine surface loss. This could, in turn, modulate dentine hypersensitivity.

AB - Objectives: To investigate the effect of toothpastes on dentine surface loss and tubule occlusion, and the association of toothpaste-related factors to each of the outcomes. Materials and methods: One hundred and sixty human dentine specimens were randomly distributed into 10 groups, according to different toothpastes. The specimens were submitted to artificial saliva (60 min), citric acid (3 min), and brushing abrasion (25 s; totalizing 2 min in toothpaste slurries). This was repeated five times and two outcome variables were analyzed: dentine surface loss (dSL; μm) and tubule occlusion by measurement of the total area of open tubules (Area-OT; μm2). Data were analyzed with Kruskal-Wallis and Mann-Whitney tests (α = 0.05); bivariate and multivariate regressions were used to model the association of the chemical (pH, concentration of F−, Ca2+, and PO4 3− and presence of Sn2+) and physical (% weight of solid particles, particle size, and wettability) factors of the toothpastes to both outcome variables. Results: Toothpastes caused different degrees of dSL and did not differ in Area-OT. All chemical and physical factors, except the presence of Sn2+, were associated with dSL (p < 0.001). Area-OT was associated only with the presence of Sn2+ (p = 0.033). Conclusion: Greater dSL was associated with lower pH, lower concentration of F−, higher concentration of Ca2+ and PO4 3−, greater % weight of solid particles, smaller particle size, and lesser wettability, whereas tubule occlusion was associated with the presence of Sn2+. Clinical relevance: Depending on their chemical and physical composition, toothpastes will cause different degrees of dentine tubule occlusion and dentine surface loss. This could, in turn, modulate dentine hypersensitivity.

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KW - Dental abrasion

KW - Dental erosion

KW - Dentinal tubules

KW - Desensitizing

KW - Toothpaste

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