Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge

S. J. Lin, J. Foley, T. X. Jiang, C. Y. Yeh, P. Wu, A. Foley, C. M. Yen, Y. C. Huang, H. C. Cheng, C. F. Chen, B. Reeder, S. H. Jee, R. B. Widelitz, C. M. Chuong

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Color patterns of bird plumage affect animal behavior and speciation. Diverse patterns are present in different species and within the individual. Here, we study the cellular and molecular basis of feather pigment pattern formation. Melanocyte progenitors are distributed as a horizontal ring in the proximal follicle, sending melanocytes vertically up into the epithelial cylinder, which gradually emerges as feathers grow. Different pigment patterns form by modulating the presence, arrangement, or differentiation of melanocytes. A layer of peripheral pulp further regulates pigmentation via patterned agouti expression. Lifetime feather cyclic regeneration resets pigment patterns for physiological needs. Thus, the evolution of stem cell niche topology allows complex pigment patterning through combinatorial co-option of simple regulatory mechanisms.

Original languageEnglish (US)
Pages (from-to)1442-1445
Number of pages4
JournalScience
Volume340
Issue number6139
DOIs
StatePublished - Jan 1 2013

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Feathers
Melanocytes
Stem Cell Niche
Animal Behavior
Pigmentation
Birds
Regeneration
Color

ASJC Scopus subject areas

  • General

Cite this

Lin, S. J., Foley, J., Jiang, T. X., Yeh, C. Y., Wu, P., Foley, A., ... Chuong, C. M. (2013). Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge. Science, 340(6139), 1442-1445. https://doi.org/10.1126/science.1230374

Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge. / Lin, S. J.; Foley, J.; Jiang, T. X.; Yeh, C. Y.; Wu, P.; Foley, A.; Yen, C. M.; Huang, Y. C.; Cheng, H. C.; Chen, C. F.; Reeder, B.; Jee, S. H.; Widelitz, R. B.; Chuong, C. M.

In: Science, Vol. 340, No. 6139, 01.01.2013, p. 1442-1445.

Research output: Contribution to journalArticle

Lin, SJ, Foley, J, Jiang, TX, Yeh, CY, Wu, P, Foley, A, Yen, CM, Huang, YC, Cheng, HC, Chen, CF, Reeder, B, Jee, SH, Widelitz, RB & Chuong, CM 2013, 'Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge', Science, vol. 340, no. 6139, pp. 1442-1445. https://doi.org/10.1126/science.1230374
Lin, S. J. ; Foley, J. ; Jiang, T. X. ; Yeh, C. Y. ; Wu, P. ; Foley, A. ; Yen, C. M. ; Huang, Y. C. ; Cheng, H. C. ; Chen, C. F. ; Reeder, B. ; Jee, S. H. ; Widelitz, R. B. ; Chuong, C. M. / Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge. In: Science. 2013 ; Vol. 340, No. 6139. pp. 1442-1445.
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