Total respiratory system compliance in asymptomatic infants with cystic fibrosis

R. S. Tepper, P. W. Hiatt, H. Eigen, J. Smith

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28 Scopus citations


Total respiratory system compliance (Crs) was assessed by the weighted spirometer method in 11 asymptomatic infants (mean age, 11.1 months) with cystic fibrosis (CF) who had normal chest radiographs. In addition to Crs, functional residual capacity (FRC), respiratory rate (RR), and mixing index (MI) were measured. There was no significant difference in FRC between normal controls (n=36) and CF infants (190 ± 69 versus 186 ± 63 ml; p<0.08), although the CF group had a higher RR (32 ± 7 versus 37 ± 7 BPM; p<0.05) and a lower MI (45 ± 7 versus 40 ± 8%; p<0.05), reflecting an abnormal distribution of ventilation. The lower Crs (9.0 ± 3.4 versus 5.7 ± 2.8 ml/cm H2O; p<0.01) and the lower specific compliance, Crs/FRC (0.049 ± 0.013 versus 0.029 ± 0.007 1/cm H2O; p<0.0001), in the CF group were the parameters that best distinguished the normal control and CF infants. We conclude that the measurement of Crs represents a noninvasive method for detecting early pulmonary function abnormalities in CF infants.

Original languageEnglish (US)
Pages (from-to)1075-1079
Number of pages5
JournalAmerican Review of Respiratory Disease
Issue number5
StatePublished - Dec 1 1987

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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