Toward an integrated neurobiology of panic disorder

Andrew W. Goddard, Dennis S. Charney

Research output: Contribution to journalReview article

115 Scopus citations


Panic disorder is a common psychiatric illness that causes considerable short- and long-term morbidity. Although drug treatment and cognitive behavior therapy are beneficial, the etiology of panic disorder and the mechanisms of effective treatment remain unclear. Developments in the preclinical neuroanatomy and neurophysiology of neuronal structures relevant to fear and anxiety promise to provide fresh insights into the neurobiology of panic. In this article, we propose a functional neuroanatomic model of fear and anxiety and review brain imaging studies of panic disorder with this model in mind. In addition, we discuss the implications of integrating functional neuroanatomy and the clinical neurochemistry of panic disorder. An integrated neurobiology of panic disorder will provide a broader conceptual framework with which to tackle the complex questions about the pathophysiology and treatment of this condition.

Original languageEnglish (US)
Pages (from-to)4-11
Number of pages8
JournalJournal of Clinical Psychiatry
Issue numberSUPPL. 2
StatePublished - Apr 7 1997

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Goddard, A. W., & Charney, D. S. (1997). Toward an integrated neurobiology of panic disorder. Journal of Clinical Psychiatry, 58(SUPPL. 2), 4-11.