Toxicity comparisons between two chemotherapy regimens as adjuvant or salvage treatment in nonseminomatous testicular cancer

R. B. Weiss, D. M. Stablein, F. M. Muggia, Lawrence Einhorn, R. B. Golbey, W. D. DeWys

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The Testicular Cancer Intergroup Study was initiated to evaluate the efficacy of adjuvant chemotherapy in Stage II and salvage therapy in Stage I nonseminomatous testicular carcinoma. Chemotherapy regimens of cisplatin, vinblastine, and bleomycin (PVB) or the same drugs plus cyclophosphamide and dactinomycin (VAB) were used at institution or cooperative group preference. A comparison of the toxicities of these two regimens shows that VAB caused significantly more mucosal, dermatologic, and otologic toxicity than PVB, and PVB caused more leucopenia. Both regimens were equally effective in controlling cancer. Either regimen could be used as chemotherapy in testicular cancer, and the decision about which one to use could be based on their differenced in toxicity and degree of patient convenience.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalCancer
Volume62
Issue number1
StatePublished - 1988
Externally publishedYes

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Salvage Therapy
Testicular Neoplasms
Drug Therapy
Vinblastine
Bleomycin
Leukopenia
Dactinomycin
Adjuvant Chemotherapy
Cyclophosphamide
Cisplatin
Carcinoma
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Weiss, R. B., Stablein, D. M., Muggia, F. M., Einhorn, L., Golbey, R. B., & DeWys, W. D. (1988). Toxicity comparisons between two chemotherapy regimens as adjuvant or salvage treatment in nonseminomatous testicular cancer. Cancer, 62(1), 18-23.

Toxicity comparisons between two chemotherapy regimens as adjuvant or salvage treatment in nonseminomatous testicular cancer. / Weiss, R. B.; Stablein, D. M.; Muggia, F. M.; Einhorn, Lawrence; Golbey, R. B.; DeWys, W. D.

In: Cancer, Vol. 62, No. 1, 1988, p. 18-23.

Research output: Contribution to journalArticle

Weiss, RB, Stablein, DM, Muggia, FM, Einhorn, L, Golbey, RB & DeWys, WD 1988, 'Toxicity comparisons between two chemotherapy regimens as adjuvant or salvage treatment in nonseminomatous testicular cancer', Cancer, vol. 62, no. 1, pp. 18-23.
Weiss, R. B. ; Stablein, D. M. ; Muggia, F. M. ; Einhorn, Lawrence ; Golbey, R. B. ; DeWys, W. D. / Toxicity comparisons between two chemotherapy regimens as adjuvant or salvage treatment in nonseminomatous testicular cancer. In: Cancer. 1988 ; Vol. 62, No. 1. pp. 18-23.
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