Toxicology of indecainide hydrochloride in mice, rats, and dogs

George Sandusky, Donald B. Meyers

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Indecainide is a new (investigational) drug for treating cardiac arrhythmias. When given orally to either young adult rats or mice, the LD50 was ca. 100 mg/kg. Leg weakness, tremors, and occasional convulsions were seen in rodents given doses in the lethal range. Dogs and monkeys survived a single oral dose of 25 mg/kg; however, there was a pronounced increase in duration of the PR and QRS intervals. In a 3-month subchronic toxicity study, rats fed dietary levels equivalent to 20 mg/kg/day indecainide were unaffected. Body weight gain was slightly depressed in both sexes of the 40-mg/kg dose group and moderately reduced in both sexes of the 85-mg/kg dose group. Alkaline phosphatase values were minimally increased in females of the 85-mg/kg dose group. In a 3-month subchronic toxicity study, dogs were given daily doses of 0, 6.25, 12.5, or 25 mg/kg indecainide. One male in the 12.5-mg/kg dose group and two females in the 25-mg/kg dose group died during the study. EKG recordings showed a prolongation of the PR and QRS intervals in all treated dogs. In addition, there was a notch in or just prior to the R wave. There were no histopathology findings related to treatment in rats and dogs in the 3-month subchronic rat and dog studies.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalFundamental and Applied Toxicology
Volume5
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Toxicology
Rats
Dogs
Toxicity
Investigational Drugs
Electrocardiography
Lethal Dose 50
Alkaline Phosphatase
Tremor
Weight Gain
Haplorhini
Cardiac Arrhythmias
Young Adult
Rodentia
Leg
Seizures
Body Weight
indecainide
Therapeutics

ASJC Scopus subject areas

  • Toxicology

Cite this

Toxicology of indecainide hydrochloride in mice, rats, and dogs. / Sandusky, George; Meyers, Donald B.

In: Fundamental and Applied Toxicology, Vol. 5, No. 1, 1985, p. 175-181.

Research output: Contribution to journalArticle

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