Toxoplasmosis in non-cardiac solid organ transplant recipients: A case series and review of literature

Poornima Ramanan, Sias Scherger, Esther Benamu, Valida Bajrovic, Whitney Jackson, Chadi A. Hage, Morgan Hakki, John W. Baddley, Maheen Z. Abidi

Research output: Contribution to journalArticle

Abstract

The risk of toxoplasmosis in high-risk cardiac transplant recipients is well recognized prompting universal donor and candidate screening with administration of targeted post-transplant chemoprophylaxis in high-risk (D+/R−) cardiac transplant patients. In contrast, until recently, there have been neither well-defined recommendations nor consensus regarding toxoplasmosis preventive strategies among non-cardiac solid organ transplant recipients. We report 3 cases of post-transplant toxoplasmosis in non-cardiac transplant recipients (one lung and two liver); all 3 infections presumed to be donor-derived. Not surprisingly, pre-transplant Toxoplasma serology was negative in all the patients. None of the patients were on trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis at the time of diagnosis of toxoplasmosis. The median time from transplant to onset of infection was 90 days (range: 30-120 days). Clinical presentations included cerebral (n = 1) and disseminated infections (n = 2). Two of the 3 patients, both with disseminated infection died (mortality ~ 67%).

Original languageEnglish (US)
Article numbere13218
JournalTransplant Infectious Disease
DOIs
StateAccepted/In press - Jan 1 2019

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Toxoplasmosis
Transplants
Infection
Donor Selection
Sulfamethoxazole Drug Combination Trimethoprim
Toxoplasma
Chemoprevention
Serology
Transplant Recipients
Tissue Donors
Lung
Mortality
Liver

Keywords

  • solid organ transplant recipients
  • toxoplasmosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

Cite this

Ramanan, P., Scherger, S., Benamu, E., Bajrovic, V., Jackson, W., Hage, C. A., ... Abidi, M. Z. (Accepted/In press). Toxoplasmosis in non-cardiac solid organ transplant recipients: A case series and review of literature. Transplant Infectious Disease, [e13218]. https://doi.org/10.1111/tid.13218

Toxoplasmosis in non-cardiac solid organ transplant recipients : A case series and review of literature. / Ramanan, Poornima; Scherger, Sias; Benamu, Esther; Bajrovic, Valida; Jackson, Whitney; Hage, Chadi A.; Hakki, Morgan; Baddley, John W.; Abidi, Maheen Z.

In: Transplant Infectious Disease, 01.01.2019.

Research output: Contribution to journalArticle

Ramanan, Poornima ; Scherger, Sias ; Benamu, Esther ; Bajrovic, Valida ; Jackson, Whitney ; Hage, Chadi A. ; Hakki, Morgan ; Baddley, John W. ; Abidi, Maheen Z. / Toxoplasmosis in non-cardiac solid organ transplant recipients : A case series and review of literature. In: Transplant Infectious Disease. 2019.
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