Trace element levels and cognitive function in rural elderly Chinese

Sujuan Gao, Yinlong Jin, Frederick Unverzagt, Feng Ma, Kathleen Hall, Jill R. Murrell, Yibin Cheng, Jianzhao Shen, Bo Ying, Rongdi Ji, Janetta Matesan, Chaoke Liang, Hugh Hendrie

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background. Trace elements are involved in metabolic processes and oxidation-reduction reactions in the central nervous system and could have a possible effect on cognitive function. The relationship between trace elements measured in individual biological samples and cognitive function in an elderly population had not been investigated extensively. Methods. The participant population is part of a large cohort study of 2000 rural elderly Chinese persons. Six cognitive assessment tests were used to evaluate cognitive function in this population, and a composite score was created to represent global cognitive function. Trace element levels of aluminum, calcium, cadmium, copper, iron, lead, and zinc were analyzed in plasma samples of 188 individuals who were randomly selected and consented to donating fasting blood. Analysis of covariance models were used to assess the association between each trace element and the composite cognitive score adjusting for demographics, medical history of chronic diseases, and the apolipoprotein E (APOE) genotype. Results. Three trace elements - calcium, cadmium, and copper - were found to be significantly related to the composite cognitive score. Increasing plasma calcium level was associated with higher cognitive score (p < .0001). Increasing cadmium and copper, in contrast, were significantly associated with lower composite score ( p = .0044 and p = .0121, respectively). Other trace elements did not show significant association with the composite cognitive score. Conclusions. Our results suggest that calcium, cadmium, and copper may be associated with cognitive function in the elderly population.

Original languageEnglish
Pages (from-to)635-641
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume63
Issue number6
StatePublished - Jun 2008

Fingerprint

Trace Elements
Cognition
Cadmium
Copper
Calcium
Population
Apolipoproteins E
Aluminum
Oxidation-Reduction
Zinc
Fasting
Chronic Disease
Cohort Studies
Iron
Central Nervous System
Genotype
Demography

Keywords

  • Cadmium
  • Calcium
  • Cognitive function
  • Copper
  • Trace element

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Trace element levels and cognitive function in rural elderly Chinese. / Gao, Sujuan; Jin, Yinlong; Unverzagt, Frederick; Ma, Feng; Hall, Kathleen; Murrell, Jill R.; Cheng, Yibin; Shen, Jianzhao; Ying, Bo; Ji, Rongdi; Matesan, Janetta; Liang, Chaoke; Hendrie, Hugh.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 63, No. 6, 06.2008, p. 635-641.

Research output: Contribution to journalArticle

Gao, S, Jin, Y, Unverzagt, F, Ma, F, Hall, K, Murrell, JR, Cheng, Y, Shen, J, Ying, B, Ji, R, Matesan, J, Liang, C & Hendrie, H 2008, 'Trace element levels and cognitive function in rural elderly Chinese', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 63, no. 6, pp. 635-641.
Gao, Sujuan ; Jin, Yinlong ; Unverzagt, Frederick ; Ma, Feng ; Hall, Kathleen ; Murrell, Jill R. ; Cheng, Yibin ; Shen, Jianzhao ; Ying, Bo ; Ji, Rongdi ; Matesan, Janetta ; Liang, Chaoke ; Hendrie, Hugh. / Trace element levels and cognitive function in rural elderly Chinese. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2008 ; Vol. 63, No. 6. pp. 635-641.
@article{7c0482c2373b43ed8d3fe59119cd65d0,
title = "Trace element levels and cognitive function in rural elderly Chinese",
abstract = "Background. Trace elements are involved in metabolic processes and oxidation-reduction reactions in the central nervous system and could have a possible effect on cognitive function. The relationship between trace elements measured in individual biological samples and cognitive function in an elderly population had not been investigated extensively. Methods. The participant population is part of a large cohort study of 2000 rural elderly Chinese persons. Six cognitive assessment tests were used to evaluate cognitive function in this population, and a composite score was created to represent global cognitive function. Trace element levels of aluminum, calcium, cadmium, copper, iron, lead, and zinc were analyzed in plasma samples of 188 individuals who were randomly selected and consented to donating fasting blood. Analysis of covariance models were used to assess the association between each trace element and the composite cognitive score adjusting for demographics, medical history of chronic diseases, and the apolipoprotein E (APOE) genotype. Results. Three trace elements - calcium, cadmium, and copper - were found to be significantly related to the composite cognitive score. Increasing plasma calcium level was associated with higher cognitive score (p < .0001). Increasing cadmium and copper, in contrast, were significantly associated with lower composite score ( p = .0044 and p = .0121, respectively). Other trace elements did not show significant association with the composite cognitive score. Conclusions. Our results suggest that calcium, cadmium, and copper may be associated with cognitive function in the elderly population.",
keywords = "Cadmium, Calcium, Cognitive function, Copper, Trace element",
author = "Sujuan Gao and Yinlong Jin and Frederick Unverzagt and Feng Ma and Kathleen Hall and Murrell, {Jill R.} and Yibin Cheng and Jianzhao Shen and Bo Ying and Rongdi Ji and Janetta Matesan and Chaoke Liang and Hugh Hendrie",
year = "2008",
month = "6",
language = "English",
volume = "63",
pages = "635--641",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Trace element levels and cognitive function in rural elderly Chinese

AU - Gao, Sujuan

AU - Jin, Yinlong

AU - Unverzagt, Frederick

AU - Ma, Feng

AU - Hall, Kathleen

AU - Murrell, Jill R.

AU - Cheng, Yibin

AU - Shen, Jianzhao

AU - Ying, Bo

AU - Ji, Rongdi

AU - Matesan, Janetta

AU - Liang, Chaoke

AU - Hendrie, Hugh

PY - 2008/6

Y1 - 2008/6

N2 - Background. Trace elements are involved in metabolic processes and oxidation-reduction reactions in the central nervous system and could have a possible effect on cognitive function. The relationship between trace elements measured in individual biological samples and cognitive function in an elderly population had not been investigated extensively. Methods. The participant population is part of a large cohort study of 2000 rural elderly Chinese persons. Six cognitive assessment tests were used to evaluate cognitive function in this population, and a composite score was created to represent global cognitive function. Trace element levels of aluminum, calcium, cadmium, copper, iron, lead, and zinc were analyzed in plasma samples of 188 individuals who were randomly selected and consented to donating fasting blood. Analysis of covariance models were used to assess the association between each trace element and the composite cognitive score adjusting for demographics, medical history of chronic diseases, and the apolipoprotein E (APOE) genotype. Results. Three trace elements - calcium, cadmium, and copper - were found to be significantly related to the composite cognitive score. Increasing plasma calcium level was associated with higher cognitive score (p < .0001). Increasing cadmium and copper, in contrast, were significantly associated with lower composite score ( p = .0044 and p = .0121, respectively). Other trace elements did not show significant association with the composite cognitive score. Conclusions. Our results suggest that calcium, cadmium, and copper may be associated with cognitive function in the elderly population.

AB - Background. Trace elements are involved in metabolic processes and oxidation-reduction reactions in the central nervous system and could have a possible effect on cognitive function. The relationship between trace elements measured in individual biological samples and cognitive function in an elderly population had not been investigated extensively. Methods. The participant population is part of a large cohort study of 2000 rural elderly Chinese persons. Six cognitive assessment tests were used to evaluate cognitive function in this population, and a composite score was created to represent global cognitive function. Trace element levels of aluminum, calcium, cadmium, copper, iron, lead, and zinc were analyzed in plasma samples of 188 individuals who were randomly selected and consented to donating fasting blood. Analysis of covariance models were used to assess the association between each trace element and the composite cognitive score adjusting for demographics, medical history of chronic diseases, and the apolipoprotein E (APOE) genotype. Results. Three trace elements - calcium, cadmium, and copper - were found to be significantly related to the composite cognitive score. Increasing plasma calcium level was associated with higher cognitive score (p < .0001). Increasing cadmium and copper, in contrast, were significantly associated with lower composite score ( p = .0044 and p = .0121, respectively). Other trace elements did not show significant association with the composite cognitive score. Conclusions. Our results suggest that calcium, cadmium, and copper may be associated with cognitive function in the elderly population.

KW - Cadmium

KW - Calcium

KW - Cognitive function

KW - Copper

KW - Trace element

UR - http://www.scopus.com/inward/record.url?scp=50949105300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50949105300&partnerID=8YFLogxK

M3 - Article

C2 - 18559640

AN - SCOPUS:50949105300

VL - 63

SP - 635

EP - 641

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 6

ER -