Tracheal lavage and plasma fibronectin: Relationship to respiratory distress syndrome and development of bronchopulmonary dysplasia

Jeffrey S. Gerdes, Mervin C. Yoder, Steven D. Douglas, Mary Paul, Mary C. Harris, Richard A. Polin

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Plasma for fibronectin determinations was obtained from 39 neonates with uncomplicated respiratory distress syndrome (RDS) and from 15 infants with RDS who developed bronchopulmonary dysplasia (BPD). Tracheal lavage fibronectin and albumin concentrations were measured in 15 infants with RDS and 15 with BPD. Control plasma fibronectin values were obtained from 20 healthy preterm infants on days 1, 2, 3, 14, and 30 of life. Control tracheal lavage fibronectin and albumin concentrations were measured in 17 neonates of various gestational ages who required tracheal intubation for nonpulmonary indications. Mean plasma fibronectin concentrations from patients with RDS was 121±11 μg/ml on days 1, 2, and 3, versus control level of 163±12 μg/ml (P<0.01). Mean tracheal lavage fibronectin/albumin ratio was 3.8±0.6 ng per microgram of albumin on days 1 to 5 for infants with RDS, versus control level of 5.6±3.6 (P=NS). Tracheal lavage fibronectin/albumin ratio from patients with BPD was elevated at 16.3±5.0 ng fibronectin per microgram of albumin on days 14 to 21, and 23.6±7.4 on day 30 (P<0.05 versus control and versus RDS days 1 to 10). Low plasma fibronectin concentrations early in RDS may contribute to the development of pulmonary capillary leak. High tracheal lavage fibronectin levels may foster the development of pulmonary fibrosis in patients with BPD.

Original languageEnglish (US)
Pages (from-to)601-606
Number of pages6
JournalThe Journal of pediatrics
Volume108
Issue number4
DOIs
StatePublished - Apr 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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