Traditional immune modulating drugs include calcineurin inhibitors, antimetabolites, and alkylating agents. Antimetabolites include purine analogues (e.g., azathioprine and mycophenolate mofetil), and folate antagonists (e.g., methotrexate and dapsone). The most widely used systemic calcineurin inhibitor is cyclosporine. The most commonly used alkylating agent is cyclophosphamide.
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