Training adaptations in skeletal muscle of juvenile diabetics

D. L. Costill, P. Cleary, W. J. Fink, C. Foster, J. L. Ivy, Frank Witzmann

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Skeletal muscles from 12 male, juvenile-onset diabetics (JD) and 13 nondiabetics (ND) were studied to determine the effects of endurance training on mitochondrial enzyme activities, lipoprotein lipase (LPL) activity, and the oxidation of lipids ( 14C-palmityl CoA) in vitro. Ten weeks of endurance running (30 min/day, 5 days/wk) resulted in 11.0 and 12.9% gains in aerobic capacity for the JD and ND groups (P>0.05), respectively. Both groups showed significant (P14C-palmityl CoA oxidation were similar for both ND and JD groups, the diabetics showed a 41% greater improvement in the measurement of muscle lipid oxidation after training than did the ND group. The principal finding of this research was that skeletal muscle of juvenile diabetics who are in moderate insulin balance shows adaptations to endurance training that are similar to those of nondiabetic men.

Original languageEnglish (US)
Pages (from-to)818-822
Number of pages5
JournalDiabetes
Volume28
Issue number9
StatePublished - 1979
Externally publishedYes

Fingerprint

Palmitoyl Coenzyme A
Skeletal Muscle
Lipids
Lipoprotein Lipase
Insulin
Muscles
Enzymes
Research
In Vitro Techniques

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Costill, D. L., Cleary, P., Fink, W. J., Foster, C., Ivy, J. L., & Witzmann, F. (1979). Training adaptations in skeletal muscle of juvenile diabetics. Diabetes, 28(9), 818-822.

Training adaptations in skeletal muscle of juvenile diabetics. / Costill, D. L.; Cleary, P.; Fink, W. J.; Foster, C.; Ivy, J. L.; Witzmann, Frank.

In: Diabetes, Vol. 28, No. 9, 1979, p. 818-822.

Research output: Contribution to journalArticle

Costill, DL, Cleary, P, Fink, WJ, Foster, C, Ivy, JL & Witzmann, F 1979, 'Training adaptations in skeletal muscle of juvenile diabetics', Diabetes, vol. 28, no. 9, pp. 818-822.
Costill DL, Cleary P, Fink WJ, Foster C, Ivy JL, Witzmann F. Training adaptations in skeletal muscle of juvenile diabetics. Diabetes. 1979;28(9):818-822.
Costill, D. L. ; Cleary, P. ; Fink, W. J. ; Foster, C. ; Ivy, J. L. ; Witzmann, Frank. / Training adaptations in skeletal muscle of juvenile diabetics. In: Diabetes. 1979 ; Vol. 28, No. 9. pp. 818-822.
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