Training Pathologists in Mouse Pathology

J. P. Sundberg, J. M. Ward, Harm HogenEsch, A. Yu Nikitin, P. M. Treuting, J. B. Macauley, P. N. Schofield

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Expertise in the pathology of mice has expanded from traditional regulatory and drug safety screening (toxicologic pathology) primarily performed by veterinary pathologists to the highly specialized area of mouse research pathobiology performed by veterinary and medical pathologists encompassing phenotyping of mutant mice and analysis of research experiments exploiting inbred mouse strains and genetically engineered lines. With increasing use of genetically modified mice in research, mouse pathobiology and, by extension, expert mouse research-oriented pathologists have become integral to the success of basic and translational biomedical research. Training for today's research-oriented mouse pathologist must go beyond knowledge of anatomic features of mice and strain-specific background diseases to the specialized genetic nomenclature, husbandry, and genetics, including the methodology of genetic engineering and complex trait analysis. While training can be accomplished through apprenticeships in formal programs, these are often heavily service related and do not provide the necessary comprehensive training. Specialty courses and short-term mentoring with expert specialists are opportunities that, when combined with active practice and publication, will lead to acquisition of the skills required for cutting-edge mouse-based experimental science.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalVeterinary Pathology
Volume49
Issue number2
DOIs
StatePublished - Mar 2012
Externally publishedYes

Fingerprint

Pathology
mice
Research
job training
Pathologists
Preclinical Drug Evaluations
Inbred Strains Mice
Translational Medical Research
Genetic Engineering
mentoring
biomedical research
Terminology
Curriculum
genetic engineering
Publications
Biomedical Research
Safety
screening
phenotype
drugs

Keywords

  • genetically engineered (GEM)
  • genetically modified
  • laboratory animals
  • mice

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Sundberg, J. P., Ward, J. M., HogenEsch, H., Nikitin, A. Y., Treuting, P. M., Macauley, J. B., & Schofield, P. N. (2012). Training Pathologists in Mouse Pathology. Veterinary Pathology, 49(2), 393-397. https://doi.org/10.1177/0300985810381244

Training Pathologists in Mouse Pathology. / Sundberg, J. P.; Ward, J. M.; HogenEsch, Harm; Nikitin, A. Yu; Treuting, P. M.; Macauley, J. B.; Schofield, P. N.

In: Veterinary Pathology, Vol. 49, No. 2, 03.2012, p. 393-397.

Research output: Contribution to journalArticle

Sundberg, JP, Ward, JM, HogenEsch, H, Nikitin, AY, Treuting, PM, Macauley, JB & Schofield, PN 2012, 'Training Pathologists in Mouse Pathology', Veterinary Pathology, vol. 49, no. 2, pp. 393-397. https://doi.org/10.1177/0300985810381244
Sundberg JP, Ward JM, HogenEsch H, Nikitin AY, Treuting PM, Macauley JB et al. Training Pathologists in Mouse Pathology. Veterinary Pathology. 2012 Mar;49(2):393-397. https://doi.org/10.1177/0300985810381244
Sundberg, J. P. ; Ward, J. M. ; HogenEsch, Harm ; Nikitin, A. Yu ; Treuting, P. M. ; Macauley, J. B. ; Schofield, P. N. / Training Pathologists in Mouse Pathology. In: Veterinary Pathology. 2012 ; Vol. 49, No. 2. pp. 393-397.
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