Trajectory of cognitive decline after incident stroke

Deborah A. Levine, Andrzej T. Galecki, Kenneth M. Langa, Frederick Unverzagt, Mohammed U. Kabeto, Bruno Giordani, Virginia G. Wadley

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

IMPORTANCE: Cognitive decline is a major cause of disability in stroke survivors. The magnitude of survivors' cognitive changes after stroke is uncertain. OBJECTIVE: To measure changes in cognitive function among survivors of incident stroke, controlling for their prestroke cognitive trajectories. DESIGN, SETTING, AND PARTICIPANTS: Prospective study of 23 572 participants 45 years or older without baseline cognitive impairment from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, residing in the continental United States, enrolled 2003-2007 and followed up through March 31, 2013. Over a median follow-up of 6.1 years (interquartile range, 5.0-7.1 years), 515 participants survived expert-adjudicated incident stroke and 23 057 remained stroke free. EXPOSURE: Time-dependent incident stroke. MAIN OUTCOMES AND MEASURES: The primary outcome was change in global cognition (Six-Item Screener [SIS], range, 0-6). Secondary outcomes were change in new learning (Consortium to Establish a Registry for Alzheimer Disease Word-List Learning; range, 0-30), verbal memory (Word-List Delayed Recall; range, 0-10), and executive function (Animal Fluency Test; range, ≥0), and cognitive impairment (SIS score

Original languageEnglish (US)
Pages (from-to)41-51
Number of pages11
JournalJournal of the American Medical Association
Volume314
Issue number1
DOIs
StatePublished - Jul 7 2015

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Stroke
Cognition
Learning
Executive Function
Cognitive Dysfunction
Registries
Alzheimer Disease
Prospective Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Levine, D. A., Galecki, A. T., Langa, K. M., Unverzagt, F., Kabeto, M. U., Giordani, B., & Wadley, V. G. (2015). Trajectory of cognitive decline after incident stroke. Journal of the American Medical Association, 314(1), 41-51. https://doi.org/10.1001/jama.2015.6968

Trajectory of cognitive decline after incident stroke. / Levine, Deborah A.; Galecki, Andrzej T.; Langa, Kenneth M.; Unverzagt, Frederick; Kabeto, Mohammed U.; Giordani, Bruno; Wadley, Virginia G.

In: Journal of the American Medical Association, Vol. 314, No. 1, 07.07.2015, p. 41-51.

Research output: Contribution to journalArticle

Levine, DA, Galecki, AT, Langa, KM, Unverzagt, F, Kabeto, MU, Giordani, B & Wadley, VG 2015, 'Trajectory of cognitive decline after incident stroke', Journal of the American Medical Association, vol. 314, no. 1, pp. 41-51. https://doi.org/10.1001/jama.2015.6968
Levine, Deborah A. ; Galecki, Andrzej T. ; Langa, Kenneth M. ; Unverzagt, Frederick ; Kabeto, Mohammed U. ; Giordani, Bruno ; Wadley, Virginia G. / Trajectory of cognitive decline after incident stroke. In: Journal of the American Medical Association. 2015 ; Vol. 314, No. 1. pp. 41-51.
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