Transcranial magnetic stimulation: Potential treatment for co-occurring alcohol, traumatic brain injury and posttraumatic stress disorders

Amy A. Herrold, Sandra L. Kletzel, Brett C. Harton, R. Chambers, Neil Jordan, Theresa Louise Bender Pape

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Alcohol use disorder (AUD), mild traumatic brain injury (mTBI), and posttraumatic stress disorder (PTSD) commonly co-occur (AUD + mTBI + PTSD). These conditions have overlapping symptoms which are, in part, reflective of overlapping neuropathology. These conditions become problematic because their co-occurrence can exacerbate symptoms. Therefore, treatments must be developed that are inclusive to all three conditions. Repetitive transcranial magnetic stimulation (rTMS) is non-invasive and may be an ideal treatment for co-occurring AUD + mTBI + PTSD. There is accumulating evidence on rTMS as a treatment for people with AUD, mTBI, and PTSD each alone. However, there are no published studies to date on rTMS as a treatment for co-occurring AUD + mTBI + PTSD. This review article advances the knowledge base for rTMS as a treatment for AUD + mTBI + PTSD. This review provides background information about these co-occurring conditions as well as rTMS. The existing literature on rTMS as a treatment for people with AUD, TBI, and PTSD each alone is reviewed. Finally, neurobiological findings in support of a theoretical model are discussed to inform TMS as a treatment for co-occurring AUD + mTBI + PTSD. The peer-reviewed literature was identified by targeted literature searches using PubMed and supplemented by cross-referencing the bibliographies of relevant review articles. The existing evidence on rTMS as a treatment for these conditions in isolation, coupled with the overlapping neuropathology and symptomology of these conditions, suggests that rTMS may be well suited for the treatment of these conditions together.

Original languageEnglish
Pages (from-to)1712-1730
Number of pages19
JournalNeural Regeneration Research
Volume9
Issue number19
DOIs
StatePublished - Oct 1 2014

Fingerprint

Transcranial Magnetic Stimulation
Brain Concussion
Post-Traumatic Stress Disorders
Alcohols
Therapeutics
Traumatic Brain Injury
Knowledge Bases
Bibliography
PubMed
Theoretical Models

Keywords

  • Addiction
  • Behavioral health
  • Co-morbidity
  • Mental health disorders
  • Neuroimaging
  • Neuroimaging
  • Non-invasive brain stimulation
  • Posttraumatic stress disorder
  • Substance use disorders
  • Transcranial magnetic stimulation
  • Traumatic brain injury
  • Treatment

ASJC Scopus subject areas

  • Developmental Neuroscience

Cite this

Transcranial magnetic stimulation : Potential treatment for co-occurring alcohol, traumatic brain injury and posttraumatic stress disorders. / Herrold, Amy A.; Kletzel, Sandra L.; Harton, Brett C.; Chambers, R.; Jordan, Neil; Pape, Theresa Louise Bender.

In: Neural Regeneration Research, Vol. 9, No. 19, 01.10.2014, p. 1712-1730.

Research output: Contribution to journalArticle

Herrold, Amy A. ; Kletzel, Sandra L. ; Harton, Brett C. ; Chambers, R. ; Jordan, Neil ; Pape, Theresa Louise Bender. / Transcranial magnetic stimulation : Potential treatment for co-occurring alcohol, traumatic brain injury and posttraumatic stress disorders. In: Neural Regeneration Research. 2014 ; Vol. 9, No. 19. pp. 1712-1730.
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