Transcriptional activation function is not required for stimulation of DNA replication by bovine papillomavirus type 1 E2

Martha J. Grossel, Francis Sverdrup, David E. Breiding, Elliot J. Androphy

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Bovine papillomavirus type 1 replication was previously shown to require both the E1 initiator protein and the E2 transactivator protein. We show here that E1, in the absence of E2, is sufficient for low-level bovine papillomavirus type 1 DNA replication in C-33A cells. In addition, studies of genetically isolated E2 point mutants demonstrate that enhancement of replication by E2 does not require its transcriptional activation function. The uncoupling of the E2 functions suggests that stimulation of transcription and replication by enhancer proteins occurs via divergent mechanisms.

Original languageEnglish (US)
Pages (from-to)7264-7269
Number of pages6
JournalJournal of virology
Volume70
Issue number10
DOIs
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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