Transcriptional regulation by STAT6

Shreevrat Goenka, Mark H. Kaplan

Research output: Contribution to journalReview article

163 Scopus citations

Abstract

Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis. In this review, we will describe our current understanding of the biological functions of STAT6 and summarize recent advances in understanding the molecular mechanisms by which STAT6 regulates transcription.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalImmunologic Research
Volume50
Issue number1
DOIs
StatePublished - May 1 2011

Keywords

  • Co-activators
  • Gene expression
  • Interleukin-4
  • Signal transducer and activator of transcription 6
  • Transcription factors

ASJC Scopus subject areas

  • Immunology

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