Transcriptional regulation by STAT6

Shreevrat Goenka, Mark H. Kaplan

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis. In this review, we will describe our current understanding of the biological functions of STAT6 and summarize recent advances in understanding the molecular mechanisms by which STAT6 regulates transcription.

Original languageEnglish
Pages (from-to)87-96
Number of pages10
JournalImmunologic Research
Volume50
Issue number1
DOIs
StatePublished - May 2011

Fingerprint

STAT Transcription Factors
Interleukin-13
Interleukin-4
Food Hypersensitivity
Atopic Dermatitis
Humoral Immunity
Immune System
Parasites
Asthma
Cytokines

Keywords

  • Co-activators
  • Gene expression
  • Interleukin-4
  • Signal transducer and activator of transcription 6
  • Transcription factors

ASJC Scopus subject areas

  • Immunology

Cite this

Transcriptional regulation by STAT6. / Goenka, Shreevrat; Kaplan, Mark H.

In: Immunologic Research, Vol. 50, No. 1, 05.2011, p. 87-96.

Research output: Contribution to journalArticle

Goenka, Shreevrat ; Kaplan, Mark H. / Transcriptional regulation by STAT6. In: Immunologic Research. 2011 ; Vol. 50, No. 1. pp. 87-96.
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