Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells

Cong Yan, Angela Naltner, Michelle Martin, Michael Naltner, Jessica M. Fangman, Okyanus Gurel

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The function of the lung is dependent upon differentiation and proliferation of respiratory epithelial cells and the synthesis/secretion of surfactant lipids and proteins into air space. During the respiratory inflammatory response, cytokines produced by macrophages and epithelial cells in the respiratory system have significant influence on surfactant protein homeostasis. We report here that among family members of Janus family tyrosine kinase (JAK) and signal transducers and activators of transcription (STAT), only JAK 1 and STAT3 stimulated the -500 to +41 promoter activity of the surfactant protein B (SP-B) gene in respiratory epithelial cells. JAK1 and STAT3 were co-localized in alveolar type II epithelial cells where SP-B is synthesized and secreted. Interleukin 6 and interleukin 11, known to activate STAT3 synergistically, stimulated the SP-B promoter activity with retinoic acid, which is at least partially mediated through interactions between STAT3 and retinoid nuclear receptor enhanceosome proteins in pulmonary epithelial cells.

Original languageEnglish (US)
Pages (from-to)10967-10972
Number of pages6
JournalJournal of Biological Chemistry
Volume277
Issue number13
DOIs
StatePublished - Mar 29 2002
Externally publishedYes

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Surface-Active Agents
Genes
Epithelial Cells
Interleukin-11
Respiratory system
Alveolar Epithelial Cells
Lung
Proteins
Macrophages
Retinoids
Transcription
Cytoplasmic and Nuclear Receptors
Tretinoin
Transducers
Respiratory System
Protein-Tyrosine Kinases
Interleukin-6
Homeostasis
Air
IgA receptor

ASJC Scopus subject areas

  • Biochemistry

Cite this

Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells. / Yan, Cong; Naltner, Angela; Martin, Michelle; Naltner, Michael; Fangman, Jessica M.; Gurel, Okyanus.

In: Journal of Biological Chemistry, Vol. 277, No. 13, 29.03.2002, p. 10967-10972.

Research output: Contribution to journalArticle

Yan, Cong ; Naltner, Angela ; Martin, Michelle ; Naltner, Michael ; Fangman, Jessica M. ; Gurel, Okyanus. / Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells. In: Journal of Biological Chemistry. 2002 ; Vol. 277, No. 13. pp. 10967-10972.
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