Transcriptome analysis and kidney research: Toward systems biology

Mingyu Liang, Allen W. Cowley, Martin J. Hessner, Jozef Lazar, David P. Basile, Jennifer L. Pietrusz

Research output: Contribution to journalArticle

20 Scopus citations


An enormous amount of data has been generated in kidney research using transcriptome analysis techniques. In this review article, we first describe briefly the principles and major characteristics of several of these techniques. We then summarize the progress in kidney research that has been made by using transcriptome analysis, emphasizing the experience gained and the lessons learned. Several technical issues regarding DNA microarray are highlighted because of the rapidly increased use of this technology. It appears clear from this brief survey that transcriptome analysis is an effective and important tool for question-driven exploratory science. To further enhance the power of this and other high throughput, as well as conventional approaches, in future studies of the kidney, we propose a multidimensional systems biology paradigm that integrates investigation at multiple levels of biologic regulation toward the goal of achieving a global understanding of physiology and pathophysiology.

Original languageEnglish (US)
Pages (from-to)2114-2122
Number of pages9
JournalKidney international
Issue number6
StatePublished - Jun 2005
Externally publishedYes


  • Gene expression
  • Genome
  • Microarray
  • Renal disease
  • Renal physiology

ASJC Scopus subject areas

  • Nephrology

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  • Cite this

    Liang, M., Cowley, A. W., Hessner, M. J., Lazar, J., Basile, D. P., & Pietrusz, J. L. (2005). Transcriptome analysis and kidney research: Toward systems biology. Kidney international, 67(6), 2114-2122.