Transformation of monocytoid B-cell lymphoma to large cell lymphoma associated with crystal-storing histiocytes

Phataraporn Thorson, Jay L. Hess

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We report a case of crystal-storing histiocytosis associated with large cell lymphoma in a patient with a history of monocytoid B-cell lymphoma 10 years previously. The cervical lymph node biopsy showed a diffuse proliferation of large lymphocytes with vesicular nuclear chromatin and distinct nucleoli. These lymphocytes were associated with numerous immunoglobulin λ light-chain crystal-storing histiocytes, which morphologically resembled rhabdomyoblasts. Occasional lymphoid cells also showed large immunoglobulin crystals. This case establishes the association of crystal-storing histiocytes with lymphomas of mucosa-associated lymphoid tissue and emphasizes the need for immunophenotyping to distinguish these unusual cases from other tumors, particularly adult rhabdomyomas.

Original languageEnglish (US)
Pages (from-to)460-462
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume124
Issue number3
StatePublished - Mar 27 2000
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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