Transforming growth factor beta-1 (TGF ?. -1) is the prototype and founding member of the TGF ? superfamily. Members of the TGF ? superfamily have important regulatory roles in a number of cellular functions, including proliferation, differentiation, chemotaxis, apoptosis, and tumor suppression. Many members of this superfamily also have profound effects on skeletal tissues, both during development and postnatally. This chapter deals with the effects of TGF ? in bone cells. It describes the physiological mechanisms for activation of TGF ? in skeletal tissues. Following this, it explains the mechanism of regulation of TGF ? by extracellular matrix proteins and discusses the specific roles and signaling pathways of the different isoforms. TGF ? has also been implicated in a number of disorders of the skeletal system. Apart from this, TGF ? has been implicated in joint degenerative diseases, such as osteoarthritis (OA) and rheumatoid arthritis (RA) and even genetically inherited disorders. Also, TGF ? is a key mediator of cancer-bone cell interactions in cancers that metastasize to bone, such as breast and prostate cancers. Finally, it states that a greater understanding of TGF ?, its effects, and its regulation would be the key to developing its potential for use as a therapeutic in disorders of skeletal metabolism.
|Original language||English (US)|
|Title of host publication||Principles of Bone Biology, Two-Volume Set|
|Number of pages||22|
|State||Published - Dec 1 2008|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)