Transient down-regulation of inhibin-βC expression following partial hepatectomy

Aurora F. Esquela, Teresa Zimmers, Leonidas Koniaris, James V. Sitzmann, Se Jin Lee

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Inhibin-βC is a recently described TGF-β family member most homologous to inhibin-βA and inhibin-βB. By Northern analysis, inhibin-βC mRNA was detected exclusively in the liver among a large number of adult mouse tissues surveyed. The expression of inhibin-βC mRNA in adult liver dropped sharply and transiently following partial hepatectomy. At 6 and 12 hours following partial hepatectomy, the levels of inhibin-βC mRNA were at least 8-fold lower than in control animals. The liver specificity of inhibin-βC expression and its down-regulation following partial hepatectomy suggest that inhibin-βC may function as a negative regulator of liver growth.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume235
Issue number3
DOIs
StatePublished - Jun 27 1997
Externally publishedYes

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Inhibins
Hepatectomy
Down-Regulation
Liver
Messenger RNA
Animals
Tissue
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Transient down-regulation of inhibin-βC expression following partial hepatectomy. / Esquela, Aurora F.; Zimmers, Teresa; Koniaris, Leonidas; Sitzmann, James V.; Lee, Se Jin.

In: Biochemical and Biophysical Research Communications, Vol. 235, No. 3, 27.06.1997, p. 553-556.

Research output: Contribution to journalArticle

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