Translation initiator EIF4G1 mutations in familial parkinson disease

Marie Christine Chartier-Harlin, Justus C. Dachsel, Carles Vilariño-Güell, Sarah J. Lincoln, Frédéric Leprêtre, Mary M. Hulihan, Jennifer Kachergus, Austen J. Milnerwood, Lucia Tapia, Mee Sook Song, Emilie Le Rhun, Eugénie Mutez, Lydie Larvor, Aurélie Duflot, Christel Vanbesien-Mailliot, Alexandre Kreisler, Owen A. Ross, Kenya Nishioka, Alexandra I. Soto-Ortolaza, Stephanie A. CobbHeather L. Melrose, Bahareh Behrouz, Brett H. Keeling, Justin A. Bacon, Emna Hentati, Lindsey Williams, Akiko Yanagiya, Nahum Sonenberg, Paul J. Lockhart, Abba C. Zubair, Ryan J. Uitti, Jan O. Aasly, Anna Krygowska-Wajs, Grzegorz Opala, Zbigniew K. Wszolek, Roberta Frigerio, Demetrius M. Maraganore, David Gosal, Tim Lynch, Michael Hutchinson, Anna Rita Bentivoglio, Enza Maria Valente, William C. Nichols, Nathan Pankratz, Tatiana Foroud, Rachel A. Gibson, Faycal Hentati, Dennis W. Dickson, Alain Destée, Matthew J. Farrer

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has implicated a locus on chromosomal region 3q26-q28. Linkage and disease segregation is explained by a missense mutation c.3614G>A (p.Arg1205His) in eukaryotic translation initiation factor 4-gamma (EIF4G1). Subsequent sequence and genotype analysis identified EIF4G1 c.1505C>T (p.Ala502Val), c.2056G>T (p.Gly686Cys), c.3490A>C (p.Ser1164Arg), c.3589C>T (p.Arg1197Trp) and c.3614G>A (p.Arg1205His) substitutions in affected subjects with familial parkinsonism and idiopathic Lewy body disease but not in control subjects. Despite different countries of origin, persons with EIF4G1 c.1505C>T (p.Ala502Val) or c.3614G>A (p.Arg1205His) mutations appear to share haplotypes consistent with ancestral founders. eIF4G1 p.Ala502Val and p.Arg1205His disrupt eIF4E or eIF3e binding, although the wild-type protein does not, and render mutant cells more vulnerable to reactive oxidative species. EIF4G1 mutations implicate mRNA translation initiation in familial parkinsonism and highlight a convergent pathway for monogenic, toxin and perhaps virally-induced Parkinson disease.

Original languageEnglish
Pages (from-to)398-406
Number of pages9
JournalAmerican Journal of Human Genetics
Volume89
Issue number3
DOIs
StatePublished - Sep 9 2011

Fingerprint

Parkinsonian Disorders
Parkinson Disease
Mutation
Eukaryotic Initiation Factor-4G
Lewy Body Disease
Protein Biosynthesis
Missense Mutation
Haplotypes
Sequence Analysis
Genotype
Genome
Proteins

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Chartier-Harlin, M. C., Dachsel, J. C., Vilariño-Güell, C., Lincoln, S. J., Leprêtre, F., Hulihan, M. M., ... Farrer, M. J. (2011). Translation initiator EIF4G1 mutations in familial parkinson disease. American Journal of Human Genetics, 89(3), 398-406. https://doi.org/10.1016/j.ajhg.2011.08.009

Translation initiator EIF4G1 mutations in familial parkinson disease. / Chartier-Harlin, Marie Christine; Dachsel, Justus C.; Vilariño-Güell, Carles; Lincoln, Sarah J.; Leprêtre, Frédéric; Hulihan, Mary M.; Kachergus, Jennifer; Milnerwood, Austen J.; Tapia, Lucia; Song, Mee Sook; Le Rhun, Emilie; Mutez, Eugénie; Larvor, Lydie; Duflot, Aurélie; Vanbesien-Mailliot, Christel; Kreisler, Alexandre; Ross, Owen A.; Nishioka, Kenya; Soto-Ortolaza, Alexandra I.; Cobb, Stephanie A.; Melrose, Heather L.; Behrouz, Bahareh; Keeling, Brett H.; Bacon, Justin A.; Hentati, Emna; Williams, Lindsey; Yanagiya, Akiko; Sonenberg, Nahum; Lockhart, Paul J.; Zubair, Abba C.; Uitti, Ryan J.; Aasly, Jan O.; Krygowska-Wajs, Anna; Opala, Grzegorz; Wszolek, Zbigniew K.; Frigerio, Roberta; Maraganore, Demetrius M.; Gosal, David; Lynch, Tim; Hutchinson, Michael; Bentivoglio, Anna Rita; Valente, Enza Maria; Nichols, William C.; Pankratz, Nathan; Foroud, Tatiana; Gibson, Rachel A.; Hentati, Faycal; Dickson, Dennis W.; Destée, Alain; Farrer, Matthew J.

In: American Journal of Human Genetics, Vol. 89, No. 3, 09.09.2011, p. 398-406.

Research output: Contribution to journalArticle

Chartier-Harlin, MC, Dachsel, JC, Vilariño-Güell, C, Lincoln, SJ, Leprêtre, F, Hulihan, MM, Kachergus, J, Milnerwood, AJ, Tapia, L, Song, MS, Le Rhun, E, Mutez, E, Larvor, L, Duflot, A, Vanbesien-Mailliot, C, Kreisler, A, Ross, OA, Nishioka, K, Soto-Ortolaza, AI, Cobb, SA, Melrose, HL, Behrouz, B, Keeling, BH, Bacon, JA, Hentati, E, Williams, L, Yanagiya, A, Sonenberg, N, Lockhart, PJ, Zubair, AC, Uitti, RJ, Aasly, JO, Krygowska-Wajs, A, Opala, G, Wszolek, ZK, Frigerio, R, Maraganore, DM, Gosal, D, Lynch, T, Hutchinson, M, Bentivoglio, AR, Valente, EM, Nichols, WC, Pankratz, N, Foroud, T, Gibson, RA, Hentati, F, Dickson, DW, Destée, A & Farrer, MJ 2011, 'Translation initiator EIF4G1 mutations in familial parkinson disease', American Journal of Human Genetics, vol. 89, no. 3, pp. 398-406. https://doi.org/10.1016/j.ajhg.2011.08.009
Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM et al. Translation initiator EIF4G1 mutations in familial parkinson disease. American Journal of Human Genetics. 2011 Sep 9;89(3):398-406. https://doi.org/10.1016/j.ajhg.2011.08.009
Chartier-Harlin, Marie Christine ; Dachsel, Justus C. ; Vilariño-Güell, Carles ; Lincoln, Sarah J. ; Leprêtre, Frédéric ; Hulihan, Mary M. ; Kachergus, Jennifer ; Milnerwood, Austen J. ; Tapia, Lucia ; Song, Mee Sook ; Le Rhun, Emilie ; Mutez, Eugénie ; Larvor, Lydie ; Duflot, Aurélie ; Vanbesien-Mailliot, Christel ; Kreisler, Alexandre ; Ross, Owen A. ; Nishioka, Kenya ; Soto-Ortolaza, Alexandra I. ; Cobb, Stephanie A. ; Melrose, Heather L. ; Behrouz, Bahareh ; Keeling, Brett H. ; Bacon, Justin A. ; Hentati, Emna ; Williams, Lindsey ; Yanagiya, Akiko ; Sonenberg, Nahum ; Lockhart, Paul J. ; Zubair, Abba C. ; Uitti, Ryan J. ; Aasly, Jan O. ; Krygowska-Wajs, Anna ; Opala, Grzegorz ; Wszolek, Zbigniew K. ; Frigerio, Roberta ; Maraganore, Demetrius M. ; Gosal, David ; Lynch, Tim ; Hutchinson, Michael ; Bentivoglio, Anna Rita ; Valente, Enza Maria ; Nichols, William C. ; Pankratz, Nathan ; Foroud, Tatiana ; Gibson, Rachel A. ; Hentati, Faycal ; Dickson, Dennis W. ; Destée, Alain ; Farrer, Matthew J. / Translation initiator EIF4G1 mutations in familial parkinson disease. In: American Journal of Human Genetics. 2011 ; Vol. 89, No. 3. pp. 398-406.
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abstract = "Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has implicated a locus on chromosomal region 3q26-q28. Linkage and disease segregation is explained by a missense mutation c.3614G>A (p.Arg1205His) in eukaryotic translation initiation factor 4-gamma (EIF4G1). Subsequent sequence and genotype analysis identified EIF4G1 c.1505C>T (p.Ala502Val), c.2056G>T (p.Gly686Cys), c.3490A>C (p.Ser1164Arg), c.3589C>T (p.Arg1197Trp) and c.3614G>A (p.Arg1205His) substitutions in affected subjects with familial parkinsonism and idiopathic Lewy body disease but not in control subjects. Despite different countries of origin, persons with EIF4G1 c.1505C>T (p.Ala502Val) or c.3614G>A (p.Arg1205His) mutations appear to share haplotypes consistent with ancestral founders. eIF4G1 p.Ala502Val and p.Arg1205His disrupt eIF4E or eIF3e binding, although the wild-type protein does not, and render mutant cells more vulnerable to reactive oxidative species. EIF4G1 mutations implicate mRNA translation initiation in familial parkinsonism and highlight a convergent pathway for monogenic, toxin and perhaps virally-induced Parkinson disease.",
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AU - Chartier-Harlin, Marie Christine

AU - Dachsel, Justus C.

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AU - Lincoln, Sarah J.

AU - Leprêtre, Frédéric

AU - Hulihan, Mary M.

AU - Kachergus, Jennifer

AU - Milnerwood, Austen J.

AU - Tapia, Lucia

AU - Song, Mee Sook

AU - Le Rhun, Emilie

AU - Mutez, Eugénie

AU - Larvor, Lydie

AU - Duflot, Aurélie

AU - Vanbesien-Mailliot, Christel

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AU - Ross, Owen A.

AU - Nishioka, Kenya

AU - Soto-Ortolaza, Alexandra I.

AU - Cobb, Stephanie A.

AU - Melrose, Heather L.

AU - Behrouz, Bahareh

AU - Keeling, Brett H.

AU - Bacon, Justin A.

AU - Hentati, Emna

AU - Williams, Lindsey

AU - Yanagiya, Akiko

AU - Sonenberg, Nahum

AU - Lockhart, Paul J.

AU - Zubair, Abba C.

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AU - Aasly, Jan O.

AU - Krygowska-Wajs, Anna

AU - Opala, Grzegorz

AU - Wszolek, Zbigniew K.

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AU - Gosal, David

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AU - Hutchinson, Michael

AU - Bentivoglio, Anna Rita

AU - Valente, Enza Maria

AU - Nichols, William C.

AU - Pankratz, Nathan

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AU - Gibson, Rachel A.

AU - Hentati, Faycal

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