Translational biomedical informatics and pharmacometrics approaches in the drug interactions research

Pengyue Zhang, Heng Yi Wu, Chien Wei Chiang, Lei Wang, Samar Binkheder, Xueying Wang, Donglin Zeng, Sara K. Quinney, Lang Li

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Drug interaction is a leading cause of adverse drug events and a major obstacle for current clinical practice. Pharmacovigilance data mining, pharmacokinetic modeling, and text mining are computation and informatic tools on integrating drug interaction knowledge and generating drug interaction hypothesis. We provide a comprehensive overview of these translational biomedical informatics methodologies with related databases. We hope this review illustrates the complementary nature of these informatic approaches and facilitates the translational drug interaction research.

Original languageEnglish (US)
Pages (from-to)90-102
Number of pages13
JournalCPT: Pharmacometrics and Systems Pharmacology
Volume7
Issue number2
DOIs
StatePublished - Feb 1 2018

ASJC Scopus subject areas

  • Modeling and Simulation
  • Pharmacology (medical)

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