Translational control gone awry: A new mechanism of tumorigenesis and novel targets of cancer treatments

Ji Ye Yin, Zizheng Dong, Zhao Qian Liu, Jian-Ting Zhang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Translational control is one of primary regulation mechanisms of gene expression. Eukaryotic translational control mainly occurs at the initiation step, the speed-limiting step, which involves more than ten translation initiation factors [eIFs (eukaryotic initiation factors)]. Changing the level or function of these eIFs results in abnormal translation of specific mRNAs and consequently abnormal growth of cells that leads to human diseases, including cancer. Accumulating evidence from recent studies showed that the expression of many eIFs was associated with malignant transformation, cancer prognosis, as well as gene expression regulation. In the present paper, we perform a critical review of recent advances in understanding the role and mechanism of eIF action in translational control and cancer as well as the possibility of targeting eIFs for therapeutic development.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalBioscience Reports
Volume31
Issue number1
DOIs
StatePublished - Feb 2011

Fingerprint

Oncology
Carcinogenesis
Gene Expression Regulation
Gene expression regulation
Eukaryotic Initiation Factors
Neoplasms
Peptide Initiation Factors
Protein Biosynthesis
Gene expression
Cells
Messenger RNA
Growth
Therapeutics

Keywords

  • Cancer therapy
  • Eukaryotic initiation factor (eIF)
  • Prognosis
  • Translational control
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Translational control gone awry : A new mechanism of tumorigenesis and novel targets of cancer treatments. / Yin, Ji Ye; Dong, Zizheng; Liu, Zhao Qian; Zhang, Jian-Ting.

In: Bioscience Reports, Vol. 31, No. 1, 02.2011, p. 1-15.

Research output: Contribution to journalArticle

Yin, Ji Ye ; Dong, Zizheng ; Liu, Zhao Qian ; Zhang, Jian-Ting. / Translational control gone awry : A new mechanism of tumorigenesis and novel targets of cancer treatments. In: Bioscience Reports. 2011 ; Vol. 31, No. 1. pp. 1-15.
@article{55ccd631fe8c40c4af28cf966209d7eb,
title = "Translational control gone awry: A new mechanism of tumorigenesis and novel targets of cancer treatments",
abstract = "Translational control is one of primary regulation mechanisms of gene expression. Eukaryotic translational control mainly occurs at the initiation step, the speed-limiting step, which involves more than ten translation initiation factors [eIFs (eukaryotic initiation factors)]. Changing the level or function of these eIFs results in abnormal translation of specific mRNAs and consequently abnormal growth of cells that leads to human diseases, including cancer. Accumulating evidence from recent studies showed that the expression of many eIFs was associated with malignant transformation, cancer prognosis, as well as gene expression regulation. In the present paper, we perform a critical review of recent advances in understanding the role and mechanism of eIF action in translational control and cancer as well as the possibility of targeting eIFs for therapeutic development.",
keywords = "Cancer therapy, Eukaryotic initiation factor (eIF), Prognosis, Translational control, Tumorigenesis",
author = "Yin, {Ji Ye} and Zizheng Dong and Liu, {Zhao Qian} and Jian-Ting Zhang",
year = "2011",
month = "2",
doi = "10.1042/BSR20100077",
language = "English",
volume = "31",
pages = "1--15",
journal = "Bioscience Reports",
issn = "0144-8463",
publisher = "Portland Press Ltd.",
number = "1",

}

TY - JOUR

T1 - Translational control gone awry

T2 - A new mechanism of tumorigenesis and novel targets of cancer treatments

AU - Yin, Ji Ye

AU - Dong, Zizheng

AU - Liu, Zhao Qian

AU - Zhang, Jian-Ting

PY - 2011/2

Y1 - 2011/2

N2 - Translational control is one of primary regulation mechanisms of gene expression. Eukaryotic translational control mainly occurs at the initiation step, the speed-limiting step, which involves more than ten translation initiation factors [eIFs (eukaryotic initiation factors)]. Changing the level or function of these eIFs results in abnormal translation of specific mRNAs and consequently abnormal growth of cells that leads to human diseases, including cancer. Accumulating evidence from recent studies showed that the expression of many eIFs was associated with malignant transformation, cancer prognosis, as well as gene expression regulation. In the present paper, we perform a critical review of recent advances in understanding the role and mechanism of eIF action in translational control and cancer as well as the possibility of targeting eIFs for therapeutic development.

AB - Translational control is one of primary regulation mechanisms of gene expression. Eukaryotic translational control mainly occurs at the initiation step, the speed-limiting step, which involves more than ten translation initiation factors [eIFs (eukaryotic initiation factors)]. Changing the level or function of these eIFs results in abnormal translation of specific mRNAs and consequently abnormal growth of cells that leads to human diseases, including cancer. Accumulating evidence from recent studies showed that the expression of many eIFs was associated with malignant transformation, cancer prognosis, as well as gene expression regulation. In the present paper, we perform a critical review of recent advances in understanding the role and mechanism of eIF action in translational control and cancer as well as the possibility of targeting eIFs for therapeutic development.

KW - Cancer therapy

KW - Eukaryotic initiation factor (eIF)

KW - Prognosis

KW - Translational control

KW - Tumorigenesis

UR - http://www.scopus.com/inward/record.url?scp=79952221509&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952221509&partnerID=8YFLogxK

U2 - 10.1042/BSR20100077

DO - 10.1042/BSR20100077

M3 - Article

C2 - 20964625

AN - SCOPUS:79952221509

VL - 31

SP - 1

EP - 15

JO - Bioscience Reports

JF - Bioscience Reports

SN - 0144-8463

IS - 1

ER -