Translational implications of the β-cell epigenome in diabetes mellitus

Justin S. Johnson, Carmella Evans-Molina

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Diabetes mellitus is a disorder of glucose homeostasis that affects more than 24 million Americans and 382 million individuals worldwide. Dysregulated insulin secretion from the pancreatic β cells plays a central role in the pathophysiology of all forms of diabetes mellitus. Therefore, an enhanced understanding of the pathways that contribute to β-cell failure is imperative. Epigenetics refers to heritable changes in DNA transcription that occur in the absence of changes to the linear DNA nucleotide sequence. Recent evidence suggests an expanding role of the β-cell epigenome in the regulation of metabolic health. The goal of this review is to discuss maladaptive changes in β-cell DNA methylation patterns and chromatin architecture, and their contribution to diabetes pathophysiology. Efforts to modulate the β-cell epigenome as a means to prevent, diagnose, and treat diabetes are also discussed.

Original languageEnglish
Pages (from-to)91-101
Number of pages11
JournalTranslational Research
Volume165
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Medical problems
Diabetes Mellitus
DNA
Transcription
Chromatin
DNA Methylation
Nucleotides
Epigenomics
Health
Insulin
Glucose
Homeostasis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, medical
  • Public Health, Environmental and Occupational Health

Cite this

Translational implications of the β-cell epigenome in diabetes mellitus. / Johnson, Justin S.; Evans-Molina, Carmella.

In: Translational Research, Vol. 165, No. 1, 01.01.2015, p. 91-101.

Research output: Contribution to journalArticle

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