Translational neurocardiology: preclinical models and cardioneural integrative aspects

J. L. Ardell, M. C. Andresen, J. A. Armour, G. E. Billman, Peng-Sheng Chen, R. D. Foreman, N. Herring, D. S. O'Leary, H. N. Sabbah, H. D. Schultz, K. Sunagawa, I. H. Zucker

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Abstract: Neuronal elements distributed throughout the cardiac nervous system, from the level of the insular cortex to the intrinsic cardiac nervous system, are in constant communication with one another to ensure that cardiac output matches the dynamic process of regional blood flow demand. Neural elements in their various ‘levels’ become differentially recruited in the transduction of sensory inputs arising from the heart, major vessels, other visceral organs and somatic structures to optimize neuronal coordination of regional cardiac function. This White Paper will review the relevant aspects of the structural and functional organization for autonomic control of the heart in normal conditions, how these systems remodel/adapt during cardiac disease, and finally how such knowledge can be leveraged in the evolving realm of autonomic regulation therapy for cardiac therapeutics.

Original languageEnglish (US)
Pages (from-to)3877-3909
Number of pages33
JournalJournal of Physiology
Volume594
Issue number14
DOIs
StatePublished - Jul 15 2016

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Nervous System
Regional Blood Flow
Cardiac Output
Cerebral Cortex
Heart Diseases
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

Ardell, J. L., Andresen, M. C., Armour, J. A., Billman, G. E., Chen, P-S., Foreman, R. D., ... Zucker, I. H. (2016). Translational neurocardiology: preclinical models and cardioneural integrative aspects. Journal of Physiology, 594(14), 3877-3909. https://doi.org/10.1113/JP271869

Translational neurocardiology : preclinical models and cardioneural integrative aspects. / Ardell, J. L.; Andresen, M. C.; Armour, J. A.; Billman, G. E.; Chen, Peng-Sheng; Foreman, R. D.; Herring, N.; O'Leary, D. S.; Sabbah, H. N.; Schultz, H. D.; Sunagawa, K.; Zucker, I. H.

In: Journal of Physiology, Vol. 594, No. 14, 15.07.2016, p. 3877-3909.

Research output: Contribution to journalArticle

Ardell, JL, Andresen, MC, Armour, JA, Billman, GE, Chen, P-S, Foreman, RD, Herring, N, O'Leary, DS, Sabbah, HN, Schultz, HD, Sunagawa, K & Zucker, IH 2016, 'Translational neurocardiology: preclinical models and cardioneural integrative aspects', Journal of Physiology, vol. 594, no. 14, pp. 3877-3909. https://doi.org/10.1113/JP271869
Ardell JL, Andresen MC, Armour JA, Billman GE, Chen P-S, Foreman RD et al. Translational neurocardiology: preclinical models and cardioneural integrative aspects. Journal of Physiology. 2016 Jul 15;594(14):3877-3909. https://doi.org/10.1113/JP271869
Ardell, J. L. ; Andresen, M. C. ; Armour, J. A. ; Billman, G. E. ; Chen, Peng-Sheng ; Foreman, R. D. ; Herring, N. ; O'Leary, D. S. ; Sabbah, H. N. ; Schultz, H. D. ; Sunagawa, K. ; Zucker, I. H. / Translational neurocardiology : preclinical models and cardioneural integrative aspects. In: Journal of Physiology. 2016 ; Vol. 594, No. 14. pp. 3877-3909.
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