Abstract
Abstract: Neuronal elements distributed throughout the cardiac nervous system, from the level of the insular cortex to the intrinsic cardiac nervous system, are in constant communication with one another to ensure that cardiac output matches the dynamic process of regional blood flow demand. Neural elements in their various ‘levels’ become differentially recruited in the transduction of sensory inputs arising from the heart, major vessels, other visceral organs and somatic structures to optimize neuronal coordination of regional cardiac function. This White Paper will review the relevant aspects of the structural and functional organization for autonomic control of the heart in normal conditions, how these systems remodel/adapt during cardiac disease, and finally how such knowledge can be leveraged in the evolving realm of autonomic regulation therapy for cardiac therapeutics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3877-3909 |
| Number of pages | 33 |
| Journal | Journal of Physiology |
| Volume | 594 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jul 15 2016 |
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ASJC Scopus subject areas
- Physiology
Cite this
Translational neurocardiology : preclinical models and cardioneural integrative aspects. / Ardell, J. L.; Andresen, M. C.; Armour, J. A.; Billman, G. E.; Chen, Peng-Sheng; Foreman, R. D.; Herring, N.; O'Leary, D. S.; Sabbah, H. N.; Schultz, H. D.; Sunagawa, K.; Zucker, I. H.
In: Journal of Physiology, Vol. 594, No. 14, 15.07.2016, p. 3877-3909.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Translational neurocardiology
T2 - preclinical models and cardioneural integrative aspects
AU - Ardell, J. L.
AU - Andresen, M. C.
AU - Armour, J. A.
AU - Billman, G. E.
AU - Chen, Peng-Sheng
AU - Foreman, R. D.
AU - Herring, N.
AU - O'Leary, D. S.
AU - Sabbah, H. N.
AU - Schultz, H. D.
AU - Sunagawa, K.
AU - Zucker, I. H.
PY - 2016/7/15
Y1 - 2016/7/15
N2 - Abstract: Neuronal elements distributed throughout the cardiac nervous system, from the level of the insular cortex to the intrinsic cardiac nervous system, are in constant communication with one another to ensure that cardiac output matches the dynamic process of regional blood flow demand. Neural elements in their various ‘levels’ become differentially recruited in the transduction of sensory inputs arising from the heart, major vessels, other visceral organs and somatic structures to optimize neuronal coordination of regional cardiac function. This White Paper will review the relevant aspects of the structural and functional organization for autonomic control of the heart in normal conditions, how these systems remodel/adapt during cardiac disease, and finally how such knowledge can be leveraged in the evolving realm of autonomic regulation therapy for cardiac therapeutics.
AB - Abstract: Neuronal elements distributed throughout the cardiac nervous system, from the level of the insular cortex to the intrinsic cardiac nervous system, are in constant communication with one another to ensure that cardiac output matches the dynamic process of regional blood flow demand. Neural elements in their various ‘levels’ become differentially recruited in the transduction of sensory inputs arising from the heart, major vessels, other visceral organs and somatic structures to optimize neuronal coordination of regional cardiac function. This White Paper will review the relevant aspects of the structural and functional organization for autonomic control of the heart in normal conditions, how these systems remodel/adapt during cardiac disease, and finally how such knowledge can be leveraged in the evolving realm of autonomic regulation therapy for cardiac therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=84978795770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978795770&partnerID=8YFLogxK
U2 - 10.1113/JP271869
DO - 10.1113/JP271869
M3 - Article
VL - 594
SP - 3877
EP - 3909
JO - Journal of Physiology
JF - Journal of Physiology
SN - 0022-3751
IS - 14
ER -