Translational Research Efforts in Biomarkers and Biology of Early Transplant-Related Complications

Sophie Paczesny, Maribel Diaz-Ricart, Enrique Carerras, Kenneth R. Cooke

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In the time since the first allogeneic hematopoietic stem cell transplantation (HSCT) was performed over 40 years ago, this life-saving procedure has been used increasingly for patients with hematologic, metabolic, and malignant diseases. Despite major advances in our understanding of the immunologic processes (both beneficial and injurious) that are associated with HSCT and improvements in supportive and critical care medicine, successful outcomes are still limited by several serious complications. As such, the establishment of effective therapeutic strategies for these complications will be crucial as increasing numbers of high-risk transplants are performed each year. The development of such approaches is fundamentally dependent upon a basic understanding of pathophysiologic mechanisms of disease and also on our ability to successfully translate these insights back to the bedside. This brief review will highlight breakthroughs in translational research endeavors that have paved the way for the development of novel strategies intended to change the standard of care and optimize outcomes for patients in whom allogeneic HSCT offers the only hope for a cure.

Original languageEnglish (US)
Pages (from-to)S101-S108
JournalBiology of Blood and Marrow Transplantation
Volume17
Issue number1 SUPPL
DOIs
StatePublished - Jan 2011
Externally publishedYes

Keywords

  • Cytokines
  • Endothelial cell (EC)
  • Graft-versus-host disease (GVHD)
  • Hematopoietic stem cell transplantation (HSCT)
  • Idiopathic pneumonia syndrome (IPS)
  • Inflammation
  • Microvasculature
  • Thrombotic microangiopathy (TMA)
  • Tumor necrosis factor alpha (TNFα)
  • Veno-occlusive disease (VOD)

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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