Transmembane potential properties of atrial cells at different sites of a spiral wave reentry: Cellular evidence for an excitable but nonexcited core

Hrayr S. Karagueuzian, Charles A. Athill, Masaaki Yashima, Takanori Ikeda, Tsu Juey Wu, William J. Mandel, Peng Sheng Chen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Transmembrane action potentials (TAPs) were recorded during simultaneous mapping of a reentrant wavefront induced in canine isolated atria. The activation pattern was visualized dynamically using a high resolution electrode catheter mapping system. During functional reentry (spiral wave), cells in the core of the spiral wave remained quiescent near their resting membrane potential. Cells away from the core progressively gained TAP amplitude and duration, and at the periphery of the spiral wave the cells generated TAPs with full height and duration. During anatomical reentry, when the tip of the wavefront remained attached to the obstacle (a condition of high source-to-sink ratio), the TAP near the obstacle had normal amplitude and duration. However, when the tip of the wavefront detached from the obstacle (condition of lowered source-to-sink ratio) the TAP lost amplitude and duration. These results are consistent with the theory that the source-to-sink ratio determines the safety factor for wave propagation and wave block near the core. With decreasing source-to-sink ratio, TAP progressively decreases in amplitude and duration. In the center of the core, the cells, while excitable, remain quiescent near their resting potential. This decrease reflects a progressive decrease in the source-to-sink ratio. TAP vanishes in the core where cells remain quiescent near their resting potential. Functional and meandering reentrant wavefronts are compatible with the spiral mechanism of reentry where block at the rotating point is provided by the steep curvature of the wave tip.

Original languageEnglish (US)
Pages (from-to)2360-2365
Number of pages6
JournalPACE - Pacing and Clinical Electrophysiology
Volume21
Issue number11 II
StatePublished - Nov 1 1998

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Membrane Potentials
Action Potentials
Canidae
Electrodes
Catheters
Safety

Keywords

  • Atrial fibrillation
  • Core
  • Meandering
  • Reentry
  • Spiral wave

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Transmembane potential properties of atrial cells at different sites of a spiral wave reentry : Cellular evidence for an excitable but nonexcited core. / Karagueuzian, Hrayr S.; Athill, Charles A.; Yashima, Masaaki; Ikeda, Takanori; Wu, Tsu Juey; Mandel, William J.; Chen, Peng Sheng.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 21, No. 11 II, 01.11.1998, p. 2360-2365.

Research output: Contribution to journalArticle

Karagueuzian, Hrayr S. ; Athill, Charles A. ; Yashima, Masaaki ; Ikeda, Takanori ; Wu, Tsu Juey ; Mandel, William J. ; Chen, Peng Sheng. / Transmembane potential properties of atrial cells at different sites of a spiral wave reentry : Cellular evidence for an excitable but nonexcited core. In: PACE - Pacing and Clinical Electrophysiology. 1998 ; Vol. 21, No. 11 II. pp. 2360-2365.
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