Transmural myocardial infarction in the dog produces sympathectomy in noninfarcted myocardium

M. J. Barber, T. M. Mueller, D. P. Henry, S. Y. Felten, D. P. Zipes

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

Because sympathetic fibers travel in the subepicardium and generally follow the coronary arteries in a basal to apical course, we tested the hypothesis that transmural myocardial infarction that involves this subepicardial region interrupts sympathetic axons traveling through the infarct and produces sympathetic denervation at noninfarcted sites apical to the infarction. A rapidly hardening vinyl latex solution injected into the first diagonal branch of the left anterior descending coronary artery produced the transmural myocardial infarction by embolizing the vasculature. Ten dogs were studied 90 minutes after coronary artery embolization (acute) and 12 dogs were studied 7-21 days after infarction (chronic). The integrity of the sympathetic innervation was tested in an open-chest preparation of the acutely and chronically infarcted dogs by measuring endocardial and epicardial effective refractory period changes during left and right stellate stimulation . Additionally, regional myocardial norepinephrine content and fluorescence were examined in the chronically infarcted dogs. Transmural infarction was verified using nitroblue tetrazolium staining. In the 10 acutely infarcted dogs, left and right stellate stimulation shortened the effective refractory period at all 56 sites examined before infarction and at 30 sites basal or lateral to the infarction after embolization. Twenty-six noninfarcted sites apical to, but not within, the zone of infarction did not respond to left or right stellate stimulation after infarction. In the 12 chronically infarcted dogs, left and right stellate stimulation shortened the effective refractory period at all 2- sites basal to infarction. In noninfarcted sites apical to the infarction, left stellate stimulation did not shorten the effective refractory period at 23 of 41 sites, while right stellate stimulation was ineffective at 24 of 41 sites. Both left and right stellate stimulation were ineffective at 18 of 41 sites. Twelve of 41 sites apical to the infarct had normal norepinephrine infusion, 0.05 μg/kg/min, i.v., shortened the refractory period at all sites apical to the infarct that did not shorten refractory period in response to stellate stimulation. In chronically infarcted dogs, myocardial norepinephrine content was reduced at the denervated sites, and histologically reduced norepinephrine fluorescence in noninfarcted, denervated myocardium was found. We conclude that transmural myocardial infarction produces heterogeneous sympathetic denervation in noninfarcted sites apical to the area of necrosis. This denervation is probably the result of interrupting sympathetic nerves coursing from base to apex.

Original languageEnglish (US)
Pages (from-to)787-796
Number of pages10
JournalCirculation
Volume67
Issue number4
StatePublished - 1983
Externally publishedYes

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Sympathectomy
Infarction
Myocardium
Myocardial Infarction
Dogs
Norepinephrine
Coronary Vessels
Fluorescence
Adrenergic Fibers
Nitroblue Tetrazolium
Latex
Denervation
Axons
Necrosis
Thorax
Staining and Labeling

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Barber, M. J., Mueller, T. M., Henry, D. P., Felten, S. Y., & Zipes, D. P. (1983). Transmural myocardial infarction in the dog produces sympathectomy in noninfarcted myocardium. Circulation, 67(4), 787-796.

Transmural myocardial infarction in the dog produces sympathectomy in noninfarcted myocardium. / Barber, M. J.; Mueller, T. M.; Henry, D. P.; Felten, S. Y.; Zipes, D. P.

In: Circulation, Vol. 67, No. 4, 1983, p. 787-796.

Research output: Contribution to journalArticle

Barber, MJ, Mueller, TM, Henry, DP, Felten, SY & Zipes, DP 1983, 'Transmural myocardial infarction in the dog produces sympathectomy in noninfarcted myocardium', Circulation, vol. 67, no. 4, pp. 787-796.
Barber MJ, Mueller TM, Henry DP, Felten SY, Zipes DP. Transmural myocardial infarction in the dog produces sympathectomy in noninfarcted myocardium. Circulation. 1983;67(4):787-796.
Barber, M. J. ; Mueller, T. M. ; Henry, D. P. ; Felten, S. Y. ; Zipes, D. P. / Transmural myocardial infarction in the dog produces sympathectomy in noninfarcted myocardium. In: Circulation. 1983 ; Vol. 67, No. 4. pp. 787-796.
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