Transplantation-mediated strategies to promote axonal regeneration following spinal cord injury

Xiao-Ming Xu, Stephen M. Onifer

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Devastating central nervous system injuries and diseases continue to occur in spite of the tremendous efforts of various prevention programs. The enormity and annual escalation of healthcare costs due to them require that therapeutic strategies be responsibly developed. The dysfunctions that occur after injury and disease are primarily due to neurotransmission damage. The last two decades of both experimental and clinical research have demonstrated that neural and non-neural tissue and cell transplantation is a viable option for ameliorating dysfunctions to markedly improve quality of life. Moreover, significant progress has been made with tissue and cell transplantation in studies of pathophysiology, plasticity, sprouting, regeneration, and functional recovery. This article will review information about the ability and potential, particularly for traumatic spinal cord injury, that neural and non-neural tissue and cell transplantation has to replace lost neurons and glia, to reconstruct damaged neural circuitry, and to restore neurotransmitters, hormones, neurotrophic factors, and neurotransmission. Donor tissues and cells to be discussed include peripheral nerve, fetal spinal cord and brain, central and peripheral nervous systems' glia, stem cells, those that have been genetically engineered, and non-neural ones. Combinatorial approaches and clinical research are also reviewed.

Original languageEnglish
Pages (from-to)171-182
Number of pages12
JournalRespiratory Physiology and Neurobiology
Volume169
Issue number2
DOIs
StatePublished - Nov 30 2009

Fingerprint

Tissue Transplantation
Cell Transplantation
Spinal Cord Injuries
Regeneration
Transplantation
Synaptic Transmission
Neuroglia
Nervous System Trauma
Central Nervous System Diseases
Peripheral Nervous System
Nerve Growth Factors
Peripheral Nerves
Research
Health Care Costs
Neurotransmitter Agents
Spinal Cord
Stem Cells
Central Nervous System
Quality of Life
Tissue Donors

Keywords

  • Plasticity
  • Regeneration
  • Spinal cord injury
  • Translation
  • Transplantation

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Transplantation-mediated strategies to promote axonal regeneration following spinal cord injury. / Xu, Xiao-Ming; Onifer, Stephen M.

In: Respiratory Physiology and Neurobiology, Vol. 169, No. 2, 30.11.2009, p. 171-182.

Research output: Contribution to journalArticle

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