Transplantation of fetal kidney cells: Neuroprotection and neuroregeneration

Yung Hsiao Chiang, Cesario V. Borlongan, Feng C. Zhou, Barry J. Hoffer, Yun Wang

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Various trophic factors in the transforming growth factor-β (TGF-β) superfamily have been reported to have neuroprotective and neuroregenerative effects. Intracerebral administration of glial cell line-derived neurotrophic factor (GDNF) or bone morphogenetic proteins (BMPs), both members of the TGF-β family, reduce ischemia- or 6-hydroxydopamine (6-OHDA)-induced injury in adult rat brain. Because BMPs and GDNF are highly expressed in fetal kidney cells, transplantation of fetal kidney tissue could serve as a cellular reservoir for such molecules and protect against neuronal injury induced by ischemia, neurotoxins, or reactive oxygen species. In this review, we discuss preclinical evidence for the efficacy of fetal kidney cell transplantation in neuroprotection and regeneration models.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalCell Transplantation
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2005

Keywords

  • Fetal kidney
  • Parkinson's disease
  • Stroke

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation

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