Transplanted raphe and hippocampal fetal neurons do not displace afferent inputs to the dorsal hippocampus from serotonergic neurons in the median raphe nucleus of the rat

Feng Zhou, Sidney B. Auerbach, Efrain C. Azmitia

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To determine if fetal transplants can substitute for or suppress intrinsic serotonergic (5-HT) innervation, we studied the relationship between transplanted and the endogenous raphe neurons projecting to the hippocampus. Fetal raphe transplants produced a 5-HT hyperinnervation of dorsal hippocampus in adult rats. Yet, transplants of fetal raphe tissue did not affect the number of median raphe nucleus (MRN) neurons, approximately 300, which retrogradely transported HRP from the hippocampus. This provides evidence that transplanted 5-HT neurons can co-exist with intrinsic 5-HT nerve terminals in the target area for at least one month. In the second part of this study, fetal hippocampal tissue was transplanted into the host hippocampus. Intrinsic 5-HT immunoreactive fibers innervated the transplanted fetal tissue. Nevertheless, the number of MRN neurons innervating the host tissue as revealed by HRP retrograde transport remained unchanged. Changes in the innervation pattern and 5-HT level in the dorsal hippocampus occur following transplantation of fetal tissue. These changes are discussed and suggest that both the target tissue and afferent neurons readjust to accommodate extrinsic transplanted tissue.

Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalBrain Research
Volume450
Issue number1-2
DOIs
StatePublished - May 31 1988

Fingerprint

Serotonergic Neurons
Raphe Nuclei
Hippocampus
Serotonin
Neurons
Fetus
Transplants
Fetal Tissue Transplantation
Afferent Neurons

Keywords

  • High-pressure liquid chromatography
  • Hippocampus
  • Horseradish peroxidase
  • Immunocytochemistry
  • Raphe
  • Serotonin
  • Transplantation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Transplanted raphe and hippocampal fetal neurons do not displace afferent inputs to the dorsal hippocampus from serotonergic neurons in the median raphe nucleus of the rat. / Zhou, Feng; Auerbach, Sidney B.; Azmitia, Efrain C.

In: Brain Research, Vol. 450, No. 1-2, 31.05.1988, p. 51-59.

Research output: Contribution to journalArticle

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