Transpupillary thermotherapy for subfoveal occult choroidal neovascularization: Effect on ocular perfusion

Thomas A. Ciulla, Alon Harris, Larry Kagemann, Ronald P. Danis, Raj Maturi, Lissa McNulty, Linda M. Pratt, Matthew Xiao, Mark H. Criswell, Dov Weinberger

Research output: Contribution to journalArticle

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Abstract

PURPOSE. To perform a descriptive analysis of the effects on ocular blood flow of transpupillary thermotherapy (TTT) for occult subfoveal choroidal neovascular membranes (CNVMs) in age-related macular degeneration (AMD). METHODS. Eleven subjects with occult subfoveal CNVM due to AMD were assessed in a masked fashion by color Doppler imaging (GDI) within 24 hours before, 24 hours after, and 1 month after undergoing TTT. RESULTS. In the posterior ciliary arteries (PCAs), there were no statistically significant changes observed in the peak systolic velocity (PSV), end diastolic velocity (EDV), or resistive index (RI) at 24 hours. At 1 month, the mean EDV decreased 36% (P = 0.0105) and the mean RI increased 3.8% (P = 0.0305) in the nasal PCA. Although there was a similar trend in the temporal PCA, the differences did not reach statistical significance. In the central retinal artery (CRA), the mean PSV decreased 16% (P = 0.0137), and the mean EDV decreased 21% (P = 0.0222) at 24 hours after treatment. There were no statistically significant differences in the CRA blood flow indices at 1 month after treatment. In the ophthalmic artery, there were no statistically significant differences observed in the mean PSV, EDV, or RI at 24 hours or 1 month after treatment. CONCLUSIONS. TTT is associated with transiently decreased volumetric blood flow in the retinal circulation 24 hours after treatment. In the posterior ciliary arteries that supply the choroid, there were no changes observed at 24 hours, but at 1 month, there was a decrease in the mean EDV and an increase in the RI in the nasal and temporal PCAs, reaching statistical significance in the nasal PCA only. This study suggests that TTT could lead to alterations in choroidal blood flow, as assessed by GDI. Further study is warranted.

Original languageEnglish (US)
Pages (from-to)3337-3340
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume42
Issue number13
StatePublished - Dec 1 2001

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Ciliary Arteries
Choroidal Neovascularization
Induced Hyperthermia
Perfusion
Guanine Nucleotide Dissociation Inhibitors
Nose
Retinal Artery
Macular Degeneration
Ophthalmic Artery
Membranes
Choroid
Therapeutics
Color

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Ciulla, T. A., Harris, A., Kagemann, L., Danis, R. P., Maturi, R., McNulty, L., ... Weinberger, D. (2001). Transpupillary thermotherapy for subfoveal occult choroidal neovascularization: Effect on ocular perfusion. Investigative Ophthalmology and Visual Science, 42(13), 3337-3340.

Transpupillary thermotherapy for subfoveal occult choroidal neovascularization : Effect on ocular perfusion. / Ciulla, Thomas A.; Harris, Alon; Kagemann, Larry; Danis, Ronald P.; Maturi, Raj; McNulty, Lissa; Pratt, Linda M.; Xiao, Matthew; Criswell, Mark H.; Weinberger, Dov.

In: Investigative Ophthalmology and Visual Science, Vol. 42, No. 13, 01.12.2001, p. 3337-3340.

Research output: Contribution to journalArticle

Ciulla, TA, Harris, A, Kagemann, L, Danis, RP, Maturi, R, McNulty, L, Pratt, LM, Xiao, M, Criswell, MH & Weinberger, D 2001, 'Transpupillary thermotherapy for subfoveal occult choroidal neovascularization: Effect on ocular perfusion', Investigative Ophthalmology and Visual Science, vol. 42, no. 13, pp. 3337-3340.
Ciulla, Thomas A. ; Harris, Alon ; Kagemann, Larry ; Danis, Ronald P. ; Maturi, Raj ; McNulty, Lissa ; Pratt, Linda M. ; Xiao, Matthew ; Criswell, Mark H. ; Weinberger, Dov. / Transpupillary thermotherapy for subfoveal occult choroidal neovascularization : Effect on ocular perfusion. In: Investigative Ophthalmology and Visual Science. 2001 ; Vol. 42, No. 13. pp. 3337-3340.
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abstract = "PURPOSE. To perform a descriptive analysis of the effects on ocular blood flow of transpupillary thermotherapy (TTT) for occult subfoveal choroidal neovascular membranes (CNVMs) in age-related macular degeneration (AMD). METHODS. Eleven subjects with occult subfoveal CNVM due to AMD were assessed in a masked fashion by color Doppler imaging (GDI) within 24 hours before, 24 hours after, and 1 month after undergoing TTT. RESULTS. In the posterior ciliary arteries (PCAs), there were no statistically significant changes observed in the peak systolic velocity (PSV), end diastolic velocity (EDV), or resistive index (RI) at 24 hours. At 1 month, the mean EDV decreased 36{\%} (P = 0.0105) and the mean RI increased 3.8{\%} (P = 0.0305) in the nasal PCA. Although there was a similar trend in the temporal PCA, the differences did not reach statistical significance. In the central retinal artery (CRA), the mean PSV decreased 16{\%} (P = 0.0137), and the mean EDV decreased 21{\%} (P = 0.0222) at 24 hours after treatment. There were no statistically significant differences in the CRA blood flow indices at 1 month after treatment. In the ophthalmic artery, there were no statistically significant differences observed in the mean PSV, EDV, or RI at 24 hours or 1 month after treatment. CONCLUSIONS. TTT is associated with transiently decreased volumetric blood flow in the retinal circulation 24 hours after treatment. In the posterior ciliary arteries that supply the choroid, there were no changes observed at 24 hours, but at 1 month, there was a decrease in the mean EDV and an increase in the RI in the nasal and temporal PCAs, reaching statistical significance in the nasal PCA only. This study suggests that TTT could lead to alterations in choroidal blood flow, as assessed by GDI. Further study is warranted.",
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T1 - Transpupillary thermotherapy for subfoveal occult choroidal neovascularization

T2 - Effect on ocular perfusion

AU - Ciulla, Thomas A.

AU - Harris, Alon

AU - Kagemann, Larry

AU - Danis, Ronald P.

AU - Maturi, Raj

AU - McNulty, Lissa

AU - Pratt, Linda M.

AU - Xiao, Matthew

AU - Criswell, Mark H.

AU - Weinberger, Dov

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N2 - PURPOSE. To perform a descriptive analysis of the effects on ocular blood flow of transpupillary thermotherapy (TTT) for occult subfoveal choroidal neovascular membranes (CNVMs) in age-related macular degeneration (AMD). METHODS. Eleven subjects with occult subfoveal CNVM due to AMD were assessed in a masked fashion by color Doppler imaging (GDI) within 24 hours before, 24 hours after, and 1 month after undergoing TTT. RESULTS. In the posterior ciliary arteries (PCAs), there were no statistically significant changes observed in the peak systolic velocity (PSV), end diastolic velocity (EDV), or resistive index (RI) at 24 hours. At 1 month, the mean EDV decreased 36% (P = 0.0105) and the mean RI increased 3.8% (P = 0.0305) in the nasal PCA. Although there was a similar trend in the temporal PCA, the differences did not reach statistical significance. In the central retinal artery (CRA), the mean PSV decreased 16% (P = 0.0137), and the mean EDV decreased 21% (P = 0.0222) at 24 hours after treatment. There were no statistically significant differences in the CRA blood flow indices at 1 month after treatment. In the ophthalmic artery, there were no statistically significant differences observed in the mean PSV, EDV, or RI at 24 hours or 1 month after treatment. CONCLUSIONS. TTT is associated with transiently decreased volumetric blood flow in the retinal circulation 24 hours after treatment. In the posterior ciliary arteries that supply the choroid, there were no changes observed at 24 hours, but at 1 month, there was a decrease in the mean EDV and an increase in the RI in the nasal and temporal PCAs, reaching statistical significance in the nasal PCA only. This study suggests that TTT could lead to alterations in choroidal blood flow, as assessed by GDI. Further study is warranted.

AB - PURPOSE. To perform a descriptive analysis of the effects on ocular blood flow of transpupillary thermotherapy (TTT) for occult subfoveal choroidal neovascular membranes (CNVMs) in age-related macular degeneration (AMD). METHODS. Eleven subjects with occult subfoveal CNVM due to AMD were assessed in a masked fashion by color Doppler imaging (GDI) within 24 hours before, 24 hours after, and 1 month after undergoing TTT. RESULTS. In the posterior ciliary arteries (PCAs), there were no statistically significant changes observed in the peak systolic velocity (PSV), end diastolic velocity (EDV), or resistive index (RI) at 24 hours. At 1 month, the mean EDV decreased 36% (P = 0.0105) and the mean RI increased 3.8% (P = 0.0305) in the nasal PCA. Although there was a similar trend in the temporal PCA, the differences did not reach statistical significance. In the central retinal artery (CRA), the mean PSV decreased 16% (P = 0.0137), and the mean EDV decreased 21% (P = 0.0222) at 24 hours after treatment. There were no statistically significant differences in the CRA blood flow indices at 1 month after treatment. In the ophthalmic artery, there were no statistically significant differences observed in the mean PSV, EDV, or RI at 24 hours or 1 month after treatment. CONCLUSIONS. TTT is associated with transiently decreased volumetric blood flow in the retinal circulation 24 hours after treatment. In the posterior ciliary arteries that supply the choroid, there were no changes observed at 24 hours, but at 1 month, there was a decrease in the mean EDV and an increase in the RI in the nasal and temporal PCAs, reaching statistical significance in the nasal PCA only. This study suggests that TTT could lead to alterations in choroidal blood flow, as assessed by GDI. Further study is warranted.

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